Ariprex 10 mg (Tablet)
Unit Price: ৳ 5.00 (6 x 5: ৳ 150.00)
Strip Price: ৳ 25.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Aripiprazole |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Schizophrenia
- Bipolar disorder
- Adjunctive treatment of major depressive disorder
- Irritability associated with autistic disorder
- Agitation associated with schizophrenia or bipolar mania
Pharmacology
- Combination of partial agonist activity at Dopamine D2 and Serotonin 5-HT 1A receptors
- Antagonist activity at Serotonin 5-HT 2A receptors
- Efficacy in improving schizophrenia, bipolar disorder, major depressive disorder, irritability associated with autistic disorder, and agitation associated with schizophrenia or bipolar disorder
Dosage
- Schizophrenia - Adults:
- Initial Dose: 10-15 mg/day
- Recommended Dose: 10-15 mg/day
- Maximum Dose: 30 mg/day
- Schizophrenia - Adolescents (13-17 years):
- Initial Dose: 2 mg/day
- Recommended Dose: 10 mg/day
- Maximum Dose: 30 mg/day
- Bipolar Mania - Adults (Monotherapy):
- Initial Dose: 15 mg/day
- Recommended Dose: 15 mg/day
- Maximum Dose: 30 mg/day
- Bipolar Mania - Adults (Adjunct to lithium or valproate):
- Initial Dose: 10-15 mg/day
- Recommended Dose: 15 mg/day
- Maximum Dose: 30 mg/day
- Bipolar Mania - Pediatric Patients (10-17 years):
- Initial Dose: 2 mg/day
- Recommended Dose: 10 mg/day
- Maximum Dose: 30 mg/day
- Major Depressive Disorder - Adults:
- Initial Dose: 2-5 mg/day
- Recommended Dose: 5-10 mg/day
- Maximum Dose: 15 mg/day
- Irritability associated with Autistic Disorder - Pediatric Patients (6-17 years):
- Initial Dose: 2 mg/day
- Recommended Dose: 5-10 mg/day
- Maximum Dose: 15 mg/day
Administration
- Oral formulations - Administer once daily without regard to meals
- IM injection - Wait at least 2 hours between doses, maximum daily dose 30 mg
Interaction
- Caution with other centrally acting drugs and alcohol
- Carbamazepine could increase Ariprex clearance and lower blood levels
- Ketoconazole, quinidine, fluoxetine, or paroxetine can inhibit Ariprex elimination and cause increased blood levels
Contraindications
- Known hypersensitivity to Aripiprazole
Side Effects
- Vomiting
- Nausea
- Akathisia
- Extrapyramidal disorder
- Somnolence
- Sedation
- Dizziness
- Insomnia
- Tremor
- Restlessness
- Fatigue
- Blurred vision
- Salivary hypersecretion
- Constipation
- Pyrexia
- Drooling
- Decreased appetite
Pregnancy & Lactation
- Pregnancy category C
- Avoid during pregnancy
- Avoid breastfeeding while receiving Aripiprazole
Precautions & Warnings
- Increased incidence of cerebrovascular adverse events in elderly patients with dementia-related psychosis
- Increased risk of suicidality in children, adolescents, young and adults with major depressive disorder when using antidepressants
- Discontinue in case of tardive dyskinesia
- Atypical antipsychotic drugs associated with metabolic changes, hyperglycemia/diabetes mellitus, dyslipidemia, and body weight gain
- Use with caution in patients with known cardiovascular or cerebrovascular disease
- Use cautiously in patients with a history of seizures
- Use caution when operating machinery
Overdose Effects
- No fatalities observed up to 1080 mg, symptoms include nausea, vomiting, asthenia, diarrhea, and somnolence
Therapeutic Class
- Atypical neuroleptic drugs
Storage Conditions
- Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.