Galfin 150 mg (Capsule)
Unit Price: ৳ 22.15 (1 x 10: ৳ 221.50)
Strip Price: ৳ 221.50
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Superficial Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
Potent inhibitor of fungal cytochrome P-450 dependent enzymes responsible for the synthesis of ergosterol
Dosage & Administration
- Adults:
- 150 mg as a single dose for Vaginal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for 14 days for Oropharyngeal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for 14-30 days for Oesophageal Candidiasis
- 150 mg weekly for 4-6 weeks for Tinea infections
- 50 mg daily for 20 days for Kerion
- 400 mg as a single dose for Pityriasis versicolor
- 150 mg weekly for 12 months for Onychomycosis
- Orally or by IV infusion, 400 mg on first day then 200-400 mg daily for invasive infections
- Orally or by IV infusion 200 mg daily for prevention of cryptococcal meningitis
- Orally or by IV infusion, 50-400 mg daily for prevention in immunocompromised patients
- Children:
- 1-2 mg/kg daily for Superficial Candidiasis
- 3-6 mg/kg daily for Systemic Candidiasis & Cryptococcal infection
- Up to 12 mg/kg daily for serious life-threatening infections
- Special Population:
- Elderly patient: Normal dose if no evidence of renal impairment
- Renal Impairment: Dosage intervals modification based on creatinine clearance
Interaction
- Interacts with warfarin, sulphonyl ureas, hydrochlorothiazide, phenytoin, rifampicin, oral contraceptives, cyclosporin, theophylline
- Administration with food, cemetidine, antacids may not impair absorption
- May decrease mean plasma clearance of theophyline by 18%
Contraindications
Hypersensitivity to Fluconazole or related triazole compounds
Side Effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Flatulence
- Rarely rash and anaphylaxis reported
Pregnancy & Lactation
Not recommended for use in pregnancy or lactation unless adequate contraception is employed
Precautions & Warnings
- Abnormalities of hepatic, renal, haematological and other biochemical function tests observed
- Hepatic necrosis reported rarely
- Rare development of exfoliative cutaneous reactions
- Use in nursing mothers not recommended
Use in Special Populations
- Elderly: Normal dose if no evidence of renal impairment
- Renal Impairment: Dosage intervals or daily dosage modification based on creatinine clearance
Overdose Effects
Supportive measures and symptomatic treatment recommended. Forced volume diuresis may increase elimination rate