Iluca 150 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Ibn sina pharmaceuticals ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Superficial Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
Triazole antifungal agent, potent inhibitor of fungal cytochrome P-450 dependent enzymes, responsible for the synthesis of ergosterol
Dosage & Administration
- Adults:
- Vaginal Candidiasis: 150 mg single dose
- Oropharyngeal Candidiasis: 200 mg 1st day, then 100 mg daily for 14 days
- Oesophageal Candidiasis: 200 mg 1st day, then 100 mg daily for 14-30 days
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
- Kerion: 50 mg daily for 20 days
- Pityriasis versicolor: 400 mg single dose
- Onychomycosis: 150 mg weekly for 12 months
- Invasive candidal infections and cryptococcal infections (including meningitis): Orally or IV infusion, 400 mg on 1st day then 200-400 mg daily
- Prevention of cryptococcal meningitis: Orally or IV infusion 200 mg daily
- Prevention of fungal infections in immunocompromised patients: Orally or IV infusion, 50-400 mg daily
- Children Over 1 Year:
- In Superficial Candidiasis: 1-2 mg/kg daily
- In Systemic Candidiasis & Cryptococcal infection: 3-6 mg/kg daily
- Use in Specific Population:
- Elderly patient: Normal dose if no evidence of renal impairment
- Renal Impairment: No adjustment in single dose therapy is required. Multiple dose therapy should be modified based on creatinine clearance
Interaction
- Increased prothrombin time after warfarin administration
- Prolonged serum half-life of oral sulphonyl ureas
- Increased plasma concentrations of hydrochlorothiazide
- Increased level of phenytoin
- Decreased AUC and shorter half-life with rifampicin
- Possible effects on combined oral contraceptives
- Slowly increased cyclosporin concentrations
- No clinically significant impairment of absorption with food, cimetidine, antacids
- Decreased mean plasma clearance of theophylline
Contraindications
Known hypersensitivity to Fluconazole or related triazole compounds
Side Effects
Nausea, abdominal discomfort, diarrhea, flatulence, rare cases of rash, rare cases of anaphylaxis
Pregnancy & Lactation
Adverse fetal effects seen in animals at high dose levels, little use during human pregnancy, not recommended in pregnancy or in women of childbearing potential unless adequate contraception is employed
Precautions & Warnings
- Abnormalities of hepatic, renal, hematological and other biochemical function tests observed in some patients
- Rare cases of hepatic necrosis observed in patients with severe underlying diseases
- Rare instances of exfoliative cutaneous reactions
- Iluca found in human breast milk at concentrations similar to plasma, not recommended during lactation
- Unlikely to impair ability to drive or use machinery
Use in Special Populations
- Elderly: Normal dose if no evidence of renal impairment
- Renal Impairment: Excreted predominantly in urine as unchanged drug. Dosage adjustment based on creatinine clearance
Overdose Effects
Supportive measures, symptomatic treatment, gastric lavage if necessary, forced volume diuresis may increase elimination rate, haemodialysis decreases plasma levels by approximately 50%
Therapeutic Class
Drugs for subcutaneous and mycoses
Storage Conditions
Keep in a dry place away from light and heat, keep out of the reach of children