Lucon 50 mg (Capsule)

Unit Price: ৳ 8.06 (3 x 10: ৳ 241.74)
Strip Price: ৳ 80.58

Medicine Details

Category Details
Generic Fluconazole
Company Navana pharmaceuticals ltd
Also available as

Indications

  • Vaginal Candidiasis
  • Oropharyngeal Candidiasis
  • Oesophageal Candidiasis
  • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
  • Kerion
  • Pityriasis versicolor
  • Onychomycosis
  • Invasive candidal infections and cryptococcal infections (including meningitis)
  • Prevention of cryptococcal meningitis
  • Prevention of fungal infections in immunocompromised patients
  • Systemic Candidiasis and Cryptococcal infection
  • Superficial Candidiasis
  • Fungal urinary tract infections
  • Disseminated candidiasis
  • Prophylaxis for fungal infection in neutropenic cancer patients
  • Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis

Pharmacology

Triazole antifungal agent

Dosage & Administration

  • Adults:
    • Vaginal Candidiasis: 150 mg as a single dose
    • Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
    • Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
    • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
    • Kerion: 50 mg daily for 20 days
    • Pityriasis versicolor: 400 mg as a single dose
    • Onychomycosis: 150 mg weekly for 12 months
    • Invasive candidal infections and cryptococcal infections: Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
    • Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
    • Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily
  • Children:
    • In Superficial Candidiasis: 1-2 mg/kg daily
    • In Systemic Candidiasis & Cryptococcal infection: 3-6 mg/kg daily
  • Use in Specific Population:
    • Elderly patient: Normal dose should be used if there is no evidence of renal impairment
    • Renal Impairment: Dosage intervals should be modified based on creatinine clearance

Interaction

  • Increased prothrombin time after warfarin administration
  • Prolonged serum half-life of concomitantly administed oral sulphonyl ureas
  • Increased plasma concentrations of fuconazole by 40% with co-administration of multiple-dose hydrochlorothiazide
  • Increased level of phenytoin
  • 25% decrease in the AUC and 20% shorter half-life of fuconazole with rifampicin administration

Contraindications

Known hypersensitivity to Fluconazole or related triazole compounds

Side Effects

  • Nausea
  • Abdominal discomfort
  • Diarrhoea
  • Fatulence
  • Rash
  • Anaphylaxis (rare)

Pregnancy & Lactation

Not recommended unless adequate contraception is employed

Precautions & Warnings

  • Abnormalities of hepatic, renal, haematological and other biochemical function tests
  • Rare exfoliative cutaneous reactions
  • Hepatic necrosis risk
  • Cutaneous reactions monitoring during therapy
  • Not recommended during lactation

Use in Special Populations

  • Elderly: Normal dose should be used if there is no evidence of renal impairment
  • Renal Impairment: Dosage intervals should be modified based on creatinine clearance

Overdose Effects

Supportive measures and symptomatic treatment, forced volume diuresis, haemodialysis

Therapeutic Class

Drugs for subcutaneous and mycoses

Storage Conditions

Dry place away from light and heat, keep out of the reach of children

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