Mycoder 50 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Superficial Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
Fluconazole is a triazole antifungal agent. It is a potent inhibitor of fungal cytochrome P-450 dependent enzymes.
Dosage & Administration
- Adults:
- Vaginal Candidiasis: 150 mg as a single dose.
- Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days.
- Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days.
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks.
- Kerion: 50 mg daily for 20 days.
- Pityriasis versicolor: 400 mg as a single dose.
- Onychomycosis: 150 mg weekly for 12 months.
- Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily.
- Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily.
- Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily.
- Use in Specific Population: Elderly patient: The normal dose should be used if there is no evidence of renal impairment.
Interaction
Fluconazole may interact with warfarin, sulphonyl ureas, hydrochlorothiazide, phenytoin, rifampicin, oral contraceptives, cyclosporin, food, cimetidine, antacids, theophylline, and other medications.
Contraindications
Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or to related triazole compounds.
Side Effects
Common side effects include symptoms associated with the gastrointestinal tract, nausea, abdominal discomfort, diarrhea, and flatulence. Rarely, adverse events such as rash and anaphylaxis have been reported.
Pregnancy & Lactation
Fluconazole adverse fetal effects have been seen in animals only at dose levels associated with maternal toxicity.
Precautions & Warnings
Abnormalities of hepatic, renal, hematological and other biochemical function tests have been observed during treatment with fluconazole in some patients, particularly those with serious underlying diseases such as AIDS and cancer.
Use in Special Populations
- Use in the elderly: The normal dose should be used if there is no evidence of renal impairment.
Overdose Effects
In the event of overdosage, supportive measures and symptomatic treatment with gastric lavage if necessary may be adequate. Forced volume diuresis would probably increase the elimination rate. Haemodialysis decreases plasma levels by approximately 50%.
Therapeutic Class
Drugs for subcutaneous and mycoses
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.