Mycoder 150 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Superficial Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
Fluconazole is a triazole antifungal agent. It is a potent inhibitor of fungal cytochrome P-450 dependent enzymes. Cytochrome P-450 enzyme system is essential component of fungal cell membrane which is responsible for the synthesis of ergosterol.
Dosage & Administration
- Adults:
- Vaginal Candidiasis: 150 mg as a single dose.
- Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days.
- Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days.
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks.
- Kerion: 50 mg daily for 20 days.
- Pityriasis versicolor: 400 mg as a single dose.
- Onychomycosis: 150 mg weekly for 12 months.
- Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily.
- Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily.
- Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily.
- Child over 1 year:
- In Superficial Candidiasis: 1-2 mg/kg daily.
- In Systemic Candidiasis & Cryptococcal infection: 3-6 mg/kg daily.
- Use in Specific Population:
- Elderly patient: The normal dose should be used if there is no evidence of renal impairment.
- Renal Impairment: No adjustment in single dose therapy is required. In multiple dose therapy of patients with renal impairment, normal doses should be given on days 1 and 2 of treatment and thereafter the dosage intervals should be modified according to renal function.
Interaction
Fluconazole may interact with various medications such as warfarin, sulphonyl ureas, hydrochlorothiazide, phenytoin, rifampicin, combined oral contraceptives, cyclosporin, theophylline, and others.
Contraindications
Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or to related triazole compounds.
Side Effects
Common side effects of Mycoder include symptoms associated with the gastrointestinal tract such as nausea, abdominal discomfort, diarrhea, and flatulence. Other adverse events such as rash are rarely encountered (Incidence less than 1%). Anaphylaxis has been reported in rare cases.
Pregnancy & Lactation
Fluconazole should not be used in pregnancy or in women of childbearing potential unless adequate contraception is employed. Its use in nursing mothers is not recommended.
Precautions & Warnings
Abnormalities of hepatic, renal, hematological, and other biochemical function tests have been observed during treatment with fluconazole in some patients. Rarely, severe cutaneous reactions such as Stevens-Johnson Syndrome and toxic epidermal necrolysis have been reported during treatment with fluconazole.
Use in Special Populations
- Elderly: The normal dose should be used if there is no evidence of renal impairment.
- Renal Impairment: Dosage intervals or daily dosage should be adjusted based on creatinine clearance in patients with renal impairment.
Overdose Effects
In the event of overdosage, supportive measures and symptomatic treatment with gastric lavage if necessary may be adequate. Forced volume diuresis and hemodialysis may also be considered.
Therapeutic Class
Drugs for subcutaneous and mycoses
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.