Nogal 50 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Kumudini pharma ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea Corporis
- Tinea Cruris
- Tinea Pedis
- Kerion
- Pityriasis Versicolor
- Onychomycosis
- Invasive Candidal Infections
- Cryptococcal Infections
- Prevention of Cryptococcal Meningitis
- Prevention of Fungal Infections in Immunocompromised Patients
- Systemic Candidiasis
- Fungal Urinary Tract Infections
- Disseminated Candidiasis
Pharmacology
Fluconazole is a triazole antifungal agent. It is a potent inhibitor of fungal cytochrome P-450 dependent enzymes.
Dosage & Administration
- Adults:
- Vaginal Candidiasis: 150 mg as a single dose
- Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
- Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
- Kerion: 50 mg daily for 20 days
- Pityriasis versicolor: 400 mg as a single dose
- Onychomycosis: 150 mg weekly for 12 months
- Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
- Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
- Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily
- Children:
- In Superficial Candidiasis: 1-2 mg/kg daily
- In Systemic Candidiasis & Cryptococcal infection: 3-6 mg/kg daily
Interactions
Fluconazole has interactions with warfarin, sulphonylureas, hydrochlorothiazide, phenytoin, rifampicin, oral contraceptives, cyclosporin, theophylline, and more.
Contraindications
Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or to related triazole compounds.
Side Effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Flatulence
- Rash
- Anaphylaxis
Pregnancy & Lactation
Fluconazole should not be used in pregnancy or in women of childbearing potential unless adequate contraception is employed.
Precautions & Warnings
- Abnormalities of hepatic, renal, haematological and other biochemical function tests have been observed
- Rarely, patients have developed exfoliative cutaneous reactions
- Use during lactation is not recommended
Use in Special Populations
- Elderly: The normal dose should be used if there is no evidence of renal impairment
- Renal Impairment: No adjustments in single dose therapy are required. In multiple dose therapy, the dosage intervals or daily dosage should be adjusted based on creatinine clearance
Overdose Effects
In the event of overdosage, supportive measures and symptomatic treatment with gastric lavage if necessary may be adequate. As fluconazole is excreted largely in the urine, forced volume diuresis would probably increase the elimination rate.
Therapeutic Class
Drugs for subcutaneous and mycoses
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.