Olif 50 mg (Capsule)
Unit Price: ৳ 8.02 (50's pack: ৳ 401.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Kemiko pharmaceuticals ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
- Triazole antifungal agent
- Potent inhibitor of fungal cytochrome P-450 dependent enzymes
- Responsible for the synthesis of ergosterol
Dosage & Administration
- Various dosages for different indications
- Adults dosages for different conditions
- Child dosages for different conditions
- Dosage modification for renal impairment
- Renal clearance in children
- Dosage adjustments in elderly patients
Interaction
- Interaction with warfarin
- Interaction with oral sulphonyl ureas
- Interaction with hydrochlorothiazide
- Interaction with phenytoin
- Interaction with rifampicin
- Interaction with combined oral contraceptives
- Interaction with cyclosporin
- No impairment of absorption with food, cemetidine, antacids or following total body irradiation
- Plasma clearance interaction with theophylline
- Potential for drug-drug interactions
Contraindications
- Known hypersensitivity to Fluconazole or related triazole compounds
Side Effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Flatulence
- Rarely encountered rash
- Rare anaphylaxis
Pregnancy & Lactation
- Adverse fetal effects in animals
- Not recommended in pregnancy or women of childbearing potential without adequate contraception
Precautions & Warnings
- Abnormalities of hepatic, renal, haematological and other biochemical function tests
- Rare occurrence of hepatic necrosis
- Exfoliative cutaneous reactions
- Use during lactation not recommended
- Unlikely to impair driving or use of machinery
Use in Special Populations
- Use in the elderly
- Dosage adjustments for renal impairment
- Renal excretion
- CrCl adjustments in renal impairment
- Haemodialysis session implications
Overdose Effects
- Supportive measures
- Symptomatic treatment
- Gastric lavage if necessary
- Forced volume diuresis
- Hemodialysis implications
Therapeutic Class
- Drugs for subcutaneous and mycoses
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children