Olif 150 mg (Capsule)
Unit Price: ৳ 22.06 (10's pack: ৳ 220.60)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Kemiko pharmaceuticals ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Superficial Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
- Triazole antifungal agent
- Inhibitor of fungal cytochrome P-450 dependent enzymes
- Responsible for the synthesis of ergosterol
Dosage & Administration
- Different dosage for various indications and patient age groups
- Oral and IV administration
- Dosage adjustment for elderly, renal impairment, and children
Interaction
- Effects on prothrombin time with warfarin
- Prolongation of serum half-life of oral sulphonylureas
- Increased plasma concentrations with hydrochlorothiazide
- Interaction with phenytoin and rifampicin
- Effects on combined oral contraceptives and cyclosporin
- Absorption interactions with food, cimetidine, and antacids
- Effects on theophylline clearance
Contraindications
- Known hypersensitivity to Fluconazole or related triazole compounds
Side Effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Fatulence
- Rarely encountered rash
- Rare cases of anaphylaxis
Pregnancy & Lactation
- Adverse fetal effects in animals at high dose levels
- Not recommended in pregnancy or women of childbearing potential without adequate contraception
Precautions & Warnings
- Observation of hepatic, renal, haematological, and biochemical function tests
- Rare occurrences of hepatic necrosis
- Development of exfoliative cutaneous reactions in rare cases
- Discontinuation in case of rash development
- Not recommended in nursing mothers
- Unlikely to impair ability to drive or use machinery
Use in Special Populations
- Use in the elderly with no evidence of renal impairment
- Dosage adjustments in renal impairment based on creatinine clearance
Overdose Effects
- Supportive and symptomatic treatment
- Potential for gastric lavage and forced volume diuresis
- Decrease in plasma levels with haemodialysis
Therapeutic Class
- Drugs for subcutaneous and mycoses
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children