Omastin 200 mg (Capsule)

Unit Price: ৳ 25.00 (1 x 10: ৳ 250.00)
Strip Price: ৳ 250.00

Medicine Details

Category Details
Generic Fluconazole
Company Beximco pharmaceuticals ltd
Also available as
Omastin 50 mg capsule Omastin 150 mg capsule Omastin 50 mg suspension Omastin 200 mg injection

Indications

  • Vaginal Candidiasis
  • Oropharyngeal Candidiasis
  • Oesophageal Candidiasis
  • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
  • Kerion
  • Pityriasis versicolor
  • Onychomycosis
  • Invasive candidal infections and cryptococcal infections (including meningitis)
  • Prevention of cryptococcal meningitis
  • Prevention of fungal infections in immunocompromised patients
  • Systemic Candidiasis and Cryptococcal infection
  • Superficial Candidiasis
  • Fungal urinary tract infections
  • Disseminated candidiasis
  • Prophylaxis for fungal infection in neutropenic cancer patients
  • Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis

Pharmacology

Potent inhibitor of fungal cytochrome P-450 dependent enzymes

Dosage & Administration

  • Adults:
    • 150 mg as a single dose for Vaginal Candidiasis
    • 200 mg in 1st day followed by 100 mg daily for 14 days for Oropharyngeal Candidiasis
    • 200 mg in 1st day followed by 100 mg daily for 14-30 days for Oesophageal Candidiasis
    • 150 mg weekly for 4-6 weeks for Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
    • 50 mg daily for 20 days for Kerion
    • 400 mg as a single dose for Pityriasis versicolor
    • 150 mg weekly for 12 months for Onychomycosis
    • Orally or by IV infusion, 400 mg on first day then 200-400 mg daily for Invasive candidal infections and cryptococcal infections (including meningitis)
    • Orally or by IV infusion 200 mg daily for Prevention of cryptococcal meningitis
    • Orally or by IV infusion, 50-400 mg daily for Prevention of fungal infections in immunocompromised patients
  • Children over 1 year:
    • 1-2 mg/kg daily for Superficial Candidiasis
    • 3-6 mg/kg daily for Systemic Candidiasis & Cryptococcal infection
  • Use in Specific Population: Dose adjustment based on creatinine clearance for Renal Impairment, Rapid renal clearance in children

Interaction

  • Potential interaction with warfarin, sulphonylureas, hydrochlorothiazide, phenytoin, rifampicin, combined oral contraceptives, cyclosporin, food, cemetidine, antacids, theophylline
  • Potential for drug-drug interactions with other medications

Contraindications

Hypersensitivity to Fluconazole or related triazole compounds

Side Effects

Common gastrointestinal symptoms, rare rash and anaphylaxis

Pregnancy & Lactation

Avoid use in pregnancy and women of child bearing potential unless adequate contraception is employed

Precautions & Warnings

  • Abnormalities: Hepatic, renal, haematological and other biochemical function tests
  • Hepatic Necrosis: Rare risk especially with multiple concomitant medications
  • Exfoliative Cutaneous Reactions: Rare reactions, especially in AIDS patients
  • Lactation: Not recommended
  • Driving/Use of machinery: Unlikely to impair ability to drive or use machinery

Use in Special Populations

  • Elderly: Normal dose if no evidence of renal impairment
  • Renal Impairment: Dose adjustment based on creatinine clearance, predominant excretion in urine

Overdose Effects

Supportive measures, symptomatic treatment, forced volume diuresis, haemodialysis

Therapeutic Class

Drugs for subcutaneous and mycoses

Storage Conditions

Keep in a dry place away from light and heat, Keep out of the reach of children

Related Brands