Omastin 50 mg/5 ml (Powder for Suspension)
35 ml bottle: ৳ 78.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Superficial Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
Triazole antifungal agent. Potent inhibitor of fungal cytochrome P-450 dependent enzymes. Responsible for the synthesis of ergosterol.
Dosage & Administration
- 150 mg as a single dose for Vaginal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for 14 days for Oropharyngeal Candidiasis
- 200 mg in 1st day followed by 100 mg daily for 14-30 days for Oesophageal Candidiasis
- 150 mg weekly for 4-6 weeks for Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- 50 mg daily for 20 days for Kerion
- 400 mg as a single dose for Pityriasis versicolor
- 150 mg weekly for 12 months for Onychomycosis
- 400 mg on first day then 200-400 mg daily for Invasive candidal infections and cryptococcal infections (including meningitis)
Interaction
- Increased prothombin time after warfarin administration
- Prolonged serum half-life of oral sulphonyl ureas
- Increased plasma concentrations of fluconazole with hydrochlorothiazide
- Increased level of phenytoin
- Decrease in AUC and shorter half-life of fluconazole with rifampicin
- No relevant effects on hormone level with combined oral contraceptive
- Slow increase in cyclosporin concentrations
- No clinically significant impairment of fluconazole absorption with food, cemetidine, antacids or following total body irradiation for bone marrow transplantation
- Decrease in mean plasma clearance of theophyline
Contraindications
Known hypersensitivity to Fluconazole or related triazole compounds
Side Effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Fatulence
- Rash (Incidence less than 1%)
- Anaphylaxis in rare cases
Pregnancy & Lactation
Adverse fetal effects seen in animals only at dose levels associated with maternal toxicity. Not recommended in pregnancy or in women of child bearing potential unless adequate contraception is employed.
Precautions & Warnings
- Abnormalities in hepatic, renal, haematological and other biochemical function tests
- Severe cutaneous reactions such as Stevens Johnson Syndrome and toxic epidermal necrolysis
- Exfoliative cutaneous reactions
- Hepatic necrosis in rare cases
- Use in nursing mothers not recommended
- Unlikely to impair ability to drive or use machinery
Use in Special Populations
- Normal dose for elderly if no evidence of renal impairment
- Dosage intervals or daily dosage adjustment for renal impairment
- Excreted predominantly in the urine as unchanged drug
- No adjustments in single dose therapy required
- Dosage intervals or daily dosage modification in accordance with creatinine clearance
Overdose Effects
Supportive measures and symptomatic treatment with gastric lavage if necessary may be adequate. Forced volume diuresis would probably increase the elimination rate. Haemodialysis decreases plasma levels by approximately 50%
Therapeutic Class
Drugs for subcutaneous and mycoses
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children