Omastin 200 mg/100 ml (IV Infusion)

100 ml bottle: ৳ 200.00

Medicine Details

Indications

  • Vaginal Candidiasis
  • Oropharyngeal Candidiasis
  • Oesophageal Candidiasis
  • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
  • Kerion
  • Pityriasis versicolor
  • Onychomycosis
  • Invasive candidal infections and cryptococcal infections (including meningitis)
  • Prevention of cryptococcal meningitis
  • Prevention of fungal infections in immunocompromised patients
  • Systemic Candidiasis and Cryptococcal infection
  • In Superficial Candidiasis
  • Fungal urinary tract infections
  • Disseminated candidiasis
  • Prophylaxis for fungal infection in neutropenic cancer patients
  • Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis

Pharmacology

  • Triazole antifungal agent
  • Potent inhibitor of fungal cytochrome P-450 dependent enzymes
  • Responsible for the synthesis of ergosterol

Dosage & Administration

  • Adults
  • Child over 1 year
  • Use in Specific Population
  • Elderly patient
  • Renal Impairment
  • Children

Interaction

  • Increased prothombin time after warfarin administration
  • Prolonged serum half-life of concomitantly administed oral sulphonyl ureas
  • Increased plasma concentrations of fuconazole by 40% with hydrochlorothiazide
  • Increased level of phenytoin
  • Phenytoin AUC decrease and shorter half-life with rifampicin
  • Combined oral contraceptive effects
  • Slowly increase cyclosporin concentrations
  • No clinically signifcant impairment of fuconazole absorption with food, cemetidine, antacids, or following total body irradiation
  • Decreased plasma clearance of theophyline

Contraindications

  • Hypersensitivity to Fluconazole or related triazole compounds

Side Effects

  • Gastrointestinal symptoms
  • Nausea
  • Abdominal discomfort
  • Diarrhoea
  • Fatulence
  • Rarely encountered rash
  • Rare cases of anaphylaxis

Pregnancy & Lactation

  • Adverse fetal effects in animals only at dose levels associated with maternal toxicity
  • Little use during human pregnancy
  • Not recommended in pregnancy or in women of child bearing potential

Precautions & Warnings

  • Abnormalities of hepatic, renal, haematological and other biochemical function tests observed in some patients
  • Rare instances of hepatic necrosis
  • Development of severe cutaneous reactions
  • Discontinuation of therapy in case of rash
  • Not recommended during lactation
  • Unlikely to impair a patient's ability to drive or use machinery

Use in Special Populations

  • Elderly
  • Renal Impairment

Overdose Effects

  • Supportive measures and symptomatic treatment
  • Gastric lavage if necessary
  • Forced volume diuresis to increase elimination rate
  • Haemodialysis to decrease plasma levels by approximately 50%

Therapeutic Class

  • Drugs for subcutaneous and mycoses

Storage Conditions

  • Dry place away from light and heat
  • Keep out of the reach of children

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