Oraf 50 mg (Capsule)

Unit Price: ৳ 8.02 (30's pack: ৳ 240.60)

Medicine Details

Category Details
Generic Fluconazole
Company Hallmark pharmaceuticals ltd
Also available as
Oraf 150 mg capsule Oraf 50 mg suspension

Indications

  • Vaginal Candidiasis
  • Oropharyngeal Candidiasis
  • Oesophageal Candidiasis
  • Tinea Infections
  • Kerion
  • Pityriasis Versicolor
  • Onychomycosis
  • Invasive Candidal Infections
  • Cryptococcal Infections
  • Fungal Urinary Tract Infections
  • Disseminated Candidiasis
  • Prophylaxis for Fungal Infection in Neutropenic Cancer Patients
  • Acute Systemic Fungal Infections

Pharmacology

Potent inhibitor of fungal cytochrome P-450 dependent enzymes

Dosage & Administration

  • Adults:
    • Vaginal Candidiasis: 150 mg as a single dose
    • Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
    • Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
    • Tinea Infections: 150 mg weekly for 4-6 weeks
    • Kerion: 50 mg daily for 20 days
    • Pityriasis Versicolor: 400 mg as a single dose
    • Onychomycosis: 150 mg weekly for 12 months
    • Invasive Candidal Infections: Orally/IV, 400 mg on first day then 200-400 mg daily
    • Prevention of Cryptococcal Meningitis: Orally/IV, 200 mg daily
    • Prevention of Fungal Infections in Immunocompromised Patients: Orally/IV, 50-400 mg daily

Interaction

  • Warfarin
  • Sulphonylureas
  • Hydrochlorothiazide
  • Phenytoin
  • Rifampicin
  • Combined Oral Contraceptives
  • Cyclosporin
  • Food/Cimetidine/Antacids/Total Body Irradiation
  • Theophylline

Contraindications

Known hypersensitivity to Fluconazole or related triazole compounds

Side Effects

  • Nausea
  • Abdominal Discomfort
  • Diarrhoea
  • Flatulence
  • Rash
  • Anaphylaxis

Pregnancy & Lactation

Not recommended in pregnancy or women of childbearing potential unless adequate contraception is employed

Precautions & Warnings

  • Hepatic, Renal, Haematological tests: Abnormalities may be observed
  • Cutaneous Reactions: Rarely developed, monitor closely
  • Use during Lactation: Not recommended
  • Driving/Use of Machinery: Therapy unlikely to impair ability

Use in Special Populations

  • Elderly: Normal dose if no evidence of renal impairment
  • Renal Impairment: Dosage intervals modified according to creatinine clearance

Overdose Effects

Supportive measures, symptomatic treatment, gastric lavage, forced volume diuresis

Therapeutic Class

Drugs for Subcutaneous and Mycoses

Storage Conditions

Keep in a dry place away from light and heat, Keep out of the reach of children

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