Oraf 50 mg/5 ml (Powder for Suspension)
35 ml bottle: ৳ 70.21
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Hallmark pharmaceuticals ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
- Triazole antifungal agent
- Inhibitor of fungal cytochrome P-450 dependent enzymes
- Potent inhibitor of fungal cell membrane synthesis of ergosterol
Dosage & Administration
- Adults:
- Vaginal Candidiasis: 150 mg as a single dose
- Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
- Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
- Kerion: 50 mg daily for 20 days
- Pityriasis versicolor: 400 mg as a single dose
- Onychomycosis: 150 mg weekly for 12 months
- Invasive candidal infections and cryptococcal infections (including meningitis): 400 mg on first day then 200-400 mg daily
- Prevention of cryptococcal meningitis: 200 mg daily
- Prevention of fungal infections in immunocompromised patients: 50-400 mg daily
Interaction
- Increased prothrombin time with warfarin
- Prolongs serum half-life of oral sulfonylureas
- Increased plasma concentrations with hydrochlorothiazide
- May increase level of phenytoin
- May decrease AUC and shorter half-life with rifampicin
- No relevant effects on hormone level with combined oral contraceptives
Contraindications
- Known hypersensitivity to Fluconazole or related triazole compounds
Side Effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Flatulence
- Rash
- Anaphylaxis (rare)
Pregnancy & Lactation
- Adverse fetal effects seen in animals at high doses
- Use not recommended in pregnancy or in women of childbearing potential unless adequate contraception is employed
Precautions & Warnings
- Abnormalities in hepatic, renal, haematological and biochemical function tests observed in some patients
- Hepatic necrosis reported in rare cases
- Developed exfoliative cutaneous reactions in rare cases
- Oraf found in human breast milk at concentrations similar to plasma
Use in Special Populations
- Use in the elderly
- Use in renal impairment
Overdose Effects
- Supportive measures and symptomatic treatment recommended
- Forced volume diuresis may increase elimination rate
- Haemodialysis decreases plasma levels by approximately 50%
Therapeutic Class
- Drugs for subcutaneous and mycoses
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children