Segal 150 mg (Capsule)

Unit Price: ৳ 22.00 (10's pack: ৳ 220.00)

Medicine Details

Category	Details
Generic	Fluconazole
Company	Supreme pharmaceutical ltd
Also available as	Segal 50 mg capsule Segal 50 mg suspension

Indications

Vaginal Candidiasis
Oropharyngeal Candidiasis
Oesophageal Candidiasis
Tinea corporis
Tinea cruris
Tinea pedis
Kerion
Pityriasis versicolor
Onychomycosis
Invasive candidal infections
Cryptococcal infections
Prevention of cryptococcal meningitis
Prevention of fungal infections in immunocompromised patients
Systemic Candidiasis
Fungal urinary tract infections
Disseminated candidiasis
Prophylaxis for fungal infection in neutropenic cancer patients
Acute treatment of other systemic fungal infections

Pharmacology

Fluconazole is a triazole antifungal agent. It is a potent inhibitor of fungal cytochrome P-450 dependent enzymes. Cytochrome P-450 enzyme system is an essential component of the fungal cell membrane, responsible for the synthesis of ergosterol.

DosageAndAdministration

Adults:
- Vaginal Candidiasis: 150 mg as a single dose
- Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
- Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
- Kerion: 50 mg daily for 20 days
- Pityriasis versicolor: 400 mg as a single dose
- Onychomycosis: 150 mg weekly for 12 months
- Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
- Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
- Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily

Interaction

Warfarin
Coumarin type anticoagulants
Hydrochlorothiazide
Phenytoin
Rifampicin
Combined oral contraceptive
Cyclosporin
Food
Cimetidine
Antacids
Theophylline

Contraindications

Known hypersensitivity to Fluconazole or related triazole compounds

SideEffects

Common:
- Nausea
- Abdominal discomfort
- Diarrhoea
- Flatulence
Rare:
- Rash
- Anaphylaxis

PregnancyAndLactation

Fluconazole adverse fetal effects observed in animals only at dose levels associated with maternal toxicity. Use in pregnancy or in women of childbearing potential unless adequate contraception is employed is not recommended.

PrecautionsAndWarnings

Abnormalities of hepatic, renal, haematological and other biochemical function tests have been observed in some patients, particularly those with serious underlying diseases such as AIDS and cancer
Rare but severe cutaneous reactions may occur, especially in AIDS patients
Use in patients with exfoliative cutaneous reactions should be closely monitored
Use during lactation is not recommended
Unlikely to impair a patient's ability to drive or use machinery

UseInSpecialPopulations

Elderly: Normal dose should be used if there is no evidence of renal impairment
RenalImpairment: No adjustments in single dose therapy are required

OverdoseEffects

In the event of overdosage, supportive measures and symptomatic treatment with gastric lavage if necessary may be adequate. Forced volume diuresis would probably increase the elimination rate.