Lucza 50 mg (Capsule)
Unit Price: ৳ 8.05 (3 x 10: ৳ 241.50)
Strip Price: ৳ 80.50
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Superficial Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
- Potent inhibitor of fungal cytochrome P-450 dependent enzymes
- Responsible for the synthesis of ergosterol
Dosage & Administration
- Different dosage for Adults
- Different dosage for Children over 1 year
- Specific dosing for Elderly patient
- Dosage modification based on Renal Impairment
- Dosing recommendation for Children in different age ranges
Interactions
- Interaction with warfarin in healthy males
- Prolongation of serum half-life of concomitantly administered oral sulphonyl ureas
- Increased plasma concentrations of fluconazole when co-administered with hydrochlorothiazide
- Increase in the level of phenytoin when co-administered with fluconazole
- Interaction with combined oral contraceptive
- Increase in cyclosporin concentrations when co-administered with fluconazole
- Effect of food, cimetidine, antacids or total body irradiation for bone marrow transplantation on fluconazole absorption
- Decrease in the mean plasma clearance of theophylline
Contraindications
- Not to be used in patients with known hypersensitivity to Fluconazole or related triazole compounds
Side Effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Fatulence
- Rash
- Anaphylaxis
Pregnancy & Lactation
- Adverse fetal effects seen in animals only at dose levels associated with maternal toxicity
- Not recommended in pregnancy or in women of childbearing potential unless adequate contraception is employed
Precautions & Warnings
- Observation of abnormalities in hepatic, renal, haematological and other biochemical function tests
- Rare occurrences of hepatic necrosis
- Development of severe cutaneous reactions such as Stevens Johnson Syndrome and toxic epidermal necrolysis
- Caution in patients with underlying diseases
- Use in lactation is not recommended
- Unlikelihood to impair a patient's ability to drive or use machinery
Use in Special Populations
- Dosage recommendations for the elderly
- Dosage modification based on Renal Impairment
Overdose Effects
- Supportive measures and symptomatic treatment
- Forced volume diuresis to increase the elimination rate
- Haemodialysis to decrease plasma levels
Therapeutic Class
- Drugs for subcutaneous and mycoses
Storage Conditions
- Dry place away from light and heat