Zolen 50 mg (Capsule)
Unit Price: ৳ 8.00 (5 x 10: ৳ 400.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Apex pharmaceuticals ltd |
| Also available as |
Title
- Zolen
Categories
- Antifungal
- Medication
- Healthcare
Description
- Zolen is a triazole antifungal agent. It is used for the treatment of various fungal infections including vaginal candidiasis, oropharyngeal candidiasis, tinea corporis, tinea cruris, tinea pedis, onychomycosis, invasive candidal and cryptococcal infections, prevention of cryptococcal meningitis, prevention of fungal infections in immunocompromised patients, and more.
Dimensions
- N/A
Color options
- N/A
Functions
- Inhibitor of fungal cytochrome P-450 dependent enzymes
- Treatment of fungal infections
- Prevention of fungal infections
Materials
- N/A
Technical specifications
- Potent inhibitor of fungal cytochrome P-450 dependent enzymes
- Excreted predominantly in the urine as unchanged drug
Design elements
- Triazole antifungal agent
- Oral and IV administration
Usability features
- Well tolerated
- Easy dosage regimen for different indications
- Suitable for elderly patients
- No impairment of driving or use of machinery
Indications
- Vaginal candidiasis
- Oropharyngeal candidiasis
- Oesophageal candidiasis
- Tinea corporis
- Tinea cruris
- Tinea pedis
- Onychomycosis
- Invasive candidal infections
- Cryptococcal infections
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections
Pharmacology
- Potent inhibitor of fungal cytochrome P-450 dependent enzymes
- Responsible for the synthesis of ergosterol
Dosage and administration
- Dosage varies for different indications
- Recommended dosage for adults and children over 1 year
- Adjustments in dosage intervals for elderly, patients with renal impairment, and children
- No adjustment in single dose therapy for patients with renal impairment
- Consideration of renal clearance in children
Interaction
- Potential interaction with warfarin, sulphonylureas, hydrochlorothiazide, phenytoin, rifampicin, oral contraceptives, cyclosporin, theophylline, food, cimetidine, antacids, and total body irradiation for bone marrow transplantation
Contraindications
- Known hypersensitivity to Fluconazole or related triazole compounds
Side effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Flatulence
- Rarely encountered adverse events such as rash
- Rare cases of anaphylaxis
Pregnancy and lactation
- Adverse fetal effects seen in animals only at very high dose levels
- Little use during human pregnancy
- Not recommended during pregnancy or in women of childbearing potential unless adequate contraception is employed
- Found in human breast milk at concentrations similar to plasma
Precautions and warnings
- Observation of hepatic, renal, haematological, and other biochemical function tests
- Rare occurrences of exfoliative cutaneous reactions
- Cautious use in patients with severe underlying diseases
- Discontinuation in case of rash in superficial fungal infection
- Not recommended during lactation
- Unlikely to impair driving or use of machinery
Use in special populations
- Recommended dosage for elderly and patients with renal impairment
- Adjustment of dosage intervals for patients with renal impairment and those receiving haemodialysis
Overdose effects
- In case of overdosage, supportive measures and symptomatic treatment recommended
- Excretion in the urine, potential for forced volume diuresis to increase elimination rate
- Haemodialysis may decrease plasma levels by approximately 50%
Therapeutic class
- Drugs for subcutaneous and mycoses
Storage conditions
- Dry place away from light and heat
- Keep out of the reach of children