Sizopra 10 mg (Tablet)
Unit Price: ৳ 5.03 (3 x 10: ৳ 150.90)
Strip Price: ৳ 50.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Aripiprazole |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Schizophrenia
- Bipolar disorder
- Adjunctive treatment of major depressive disorder
- Irritability associated with autistic disorder
- Agitation associated with schizophrenia or bipolar mania
Pharmacology
Aripiprazole is an atypical antipsychotic with partial agonist activity at Dopamine D2 and Serotonin 5-HT 1A receptors and antagonist activity at Serotonin 5-HT 2A receptors
Dosage
- Schizophrenia - Adults:
- Initial Dose: 10-15 mg/day
- Recommended Dose: 10-15 mg/day
- Maximum Dose: 30 mg/day
- Schizophrenia - Adolescents:
- Initial Dose: 2 mg/day
- Recommended Dose: 10 mg/day
- Maximum Dose: 30 mg/day
- Bipolar Mania - Adults (Monotherapy):
- Initial Dose: 15 mg/day
- Recommended Dose: 15 mg/day
- Maximum Dose: 30 mg/day
- Bipolar Mania - Adults (Adjunct to lithium or valproate):
- Initial Dose: 10-15 mg/day
- Recommended Dose: 15 mg/day
- Maximum Dose: 30 mg/day
- Bipolar Mania - Pediatric patients:
- Initial Dose: 2 mg/day
- Recommended Dose: 10 mg/day
- Maximum Dose: 30 mg/day
- Major Depressive Disorder - Adults:
- Initial Dose: 2-5 mg/day
- Recommended Dose: 5-10 mg/day
- Maximum Dose: 15 mg/day
- Irritability associated with autistic disorder - Pediatric patients:
- Initial Dose: 2 mg/day
- Recommended Dose: 5-10 mg/day
- Maximum Dose: 15 mg/day
Administration
- Oral formulations: Administer once daily without regard to meals
- IM injection: Wait at least 2 hours between doses. Maximum daily dose 30 mg
Interaction
Caution advised when taken with centrally acting drugs and alcohol. Carbamazepine could increase clearance, while ketoconazole, quinidine, fluoxetine, or paroxetine could inhibit elimination.
Contraindications
Known hypersensitivity to Aripiprazole
Side Effects
- Vomiting
- Nausea
- Akathisia
- Extrapyramidal disorder
- Somnolence
- Sedation
- Dizziness
- Insomnia
- Tremor
- Restlessness
- Fatigue
- Blurred vision
- Salivary hypersecretion
- Constipation
- Pyrexia
- Drooling
- Decreased appetite
Pregnancy & Lactation
- Category: C
- Recommendation: Avoid during pregnancy. Not recommended for breastfeeding women
Precautions & Warnings
- Elderly Patients with Dementia-Related Psychosis: Increased incidence of cerebrovascular adverse events
- Suicidality & Antidepressants: Increased risk of suicidality in certain populations
- Tardive Dyskinesia: Discontinue if appropriate
- Metabolic Changes: Atypical antipsychotic drugs have been associated with metabolic changes including hyperglycemia, dyslipidemia, and body weight gain
- Orthostatic Hypotension: Use with caution in patients with known cardiovascular or cerebrovascular disease
- Seizures/Convulsions: Use cautiously in patients with a history of seizures
- Operate Machinery: Use caution
Overdose Effects
No fatalities observed at doses up to 1080 mg. Symptoms include nausea, vomiting, asthenia, diarrhea, and somnolence
Therapeutic Class
Atypical neuroleptic drugs
Storage Conditions
Keep below 30°C, away from light & moisture. Keep out of the reach of children