Zolen 150 mg (Capsule)

Unit Price: ৳ 20.00 (1 x 10: ৳ 200.00)

Strip Price: ৳ 200.00

Medicine Details

Vaginal Candidiasis
Oropharyngeal Candidiasis
Oesophageal Candidiasis
Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
Kerion
Pityriasis versicolor
Onychomycosis
Invasive candidal infections and cryptococcal infections (including meningitis)
Prevention of cryptococcal meningitis
Prevention of fungal infections in immunocompromised patients
Systemic Candidiasis and Cryptococcal infection
Superficial Candidiasis
Fungal urinary tract infections
Disseminated candidiasis
Prophylaxis for fungal infection in neutropenic cancer patients
Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis

Potent inhibitor of fungal cytochrome P-450 dependent enzymes

Adults:
- Vaginal Candidiasis: 150 mg as a single dose
- Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
- Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
- Kerion: 50 mg daily for 20 days
- Pityriasis versicolor: 400 mg as a single dose
- Onychomycosis: 150 mg weekly for 12 months
- Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
- Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
- Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily
Child over 1 year:
- In Superficial Candidiasis: 1-2 mg/kg daily
- In Systemic Candidiasis & Cryptococcal infection:3-6 mg/kg daily
Use in Specific Population:
- Elderly patient: The normal dose should be used if there is no evidence of renal impairment
- Renal Impairment:
  - Creatinine clearance (>41 ml/min): Dosage interval (hours) 24
  - Creatinine clearance (21-40 ml/min): Dosage interval (hours) 48
  - Creatinine clearance (10-20 ml/min): Dosage interval (hours) 72
  - Patients receiving regular dialysis: One dose after every dialysis session
- Children: Renal clearance in children may be proportionately more rapid than in adults and doses up to 12 mg/kg is recommended

Increased prothrombin time after warfarin administration
Prolongation of serum half-life of concomitantly administered oral sulphonylureas
Increase in plasma concentrations of fluconazole when co-administered with hydrochlorothiazide
Increase in the level of phenytoin when co-administered with fluconazole
Affects on combined oral contraceptive, cyclosporin levels, theophylline clearance
No clinically significant impairment of fluconazole absorption when co-administered with food, cimetidine, antacids, or following total body irradiation
Decrease in mean plasma clearance of theophylline when administered with fluconazole
Potential drug-drug interactions with other medications

Hypersensitivity to Fluconazole or related triazole compounds

Not recommended for use in pregnancy or in women of childbearing potential unless adequate contraception is employed

Abnormalities of hepatic, renal, hematological and other biochemical function tests observed in some patients
Rare cases of hepatic necrosis observed in patients with serious underlying diseases
Rare development of exfoliative cutaneous reactions
Use not recommended during lactation
Unlikely to impair a patient's ability to drive or use machinery

Elderly: The normal dose should be used if there is no evidence of renal impairment
Renal Impairment:
- CrCl >40: Dosage interval 24 hours (normal dosage regimen)
- CrCl 21-40: Dosage interval 48 hours or half normal daily dose
- CrCl 10-20: Dosage interval 72 hours or one-third normal daily dose
- Patients receiving regular haemodialysis: One dose after every dialysis session

Supportive measures and symptomatic treatment with gastric lavage, forced volume diuresis, or haemodialysis if necessary