Limastin 50 mg (Capsule)
Unit Price: ৳ 8.00 (30's pack: ৳ 240.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Oyster pharmaceuticals ltd |
Title
- Limastin Antifungal Medicine
Categories
- Antifungal
- Medicine
- Pharmaceutical
Description
- Fluconazole is a potent inhibitor of fungal cytochrome P-450 dependent enzymes.
- Well tolerated with common side effects being gastrointestinal symptoms.
- Should not be used in patients with known hypersensitivity to fluconazole or related triazole compounds.
- Not recommended for use in pregnancy or during lactation.
- Should be stored in a dry place away from light and heat, and kept out of the reach of children.
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Mode of Action
- Potent inhibitor of fungal cytochrome P-450 dependent enzymes.
- Essential component of fungal cell membrane responsible for the synthesis of ergosterol.
Dosage and Administration
- Adults
- Child over 1 year
- Use in specific population (Elderly patients, Renal impairment)
- Doses up to 12 mg/kg for children aged 5-13 years
Interaction
- Interacts with warfarin, sulphonyl ureas, hydrochlorothiazide, phenytoin, rifampicin, oral contraceptives, cyclosporin, food, cemetidine, antacids, theophylline.
Contraindications
- Known hypersensitivity to fluconazole or related triazole compounds.
Side Effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Flatulence
- Rare cases of rash
- Rare reports of anaphylaxis
Pregnancy and Lactation
- Adverse fetal effects seen in animals at high doses
- Not recommended during pregnancy or in women of childbearing potential unless adequate contraception is employed.
- Found in human breast milk at concentrations similar to plasma, not recommended during lactation.
Precautions and Warnings
- Abnormalities of hepatic, renal, haematological, and biochemical function tests in some patients
- Rare cases of hepatotoxicity
- Rare development of exfoliative cutaneous reactions
- Caution in patients with serious underlying diseases like AIDS and cancer
- Discontinue if rash develops during treatment
- Caution in patients with invasive/systemic fungal infections who develop rashes
- Not recommended during lactation
Use in Special Populations
- Use in the elderly
- Use in renal impairment, dosage adjustments based on creatinine clearance
- Excreted predominantly in urine
- Monitoring recommended in patients receiving haemodialysis
Overdose Effects
- Supportive measures and symptomatic treatment
- Forced volume diuresis may increase elimination rate
- Haemodialysis can decrease plasma levels by approximately 50%
Therapeutic Class
- Drugs for subcutaneous and mycoses
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children