Acyclovir + Hydrocortisone
Generic Details
Generic Name
Acyclovir-Hydrocortisone
Other Names
- Acyclovir and Hydrocortisone Cream
Drug Class
- Antiviral
- Corticosteroid
Chemical Formula
Molecular Weight
Mechanism of Action
- Acyclovir: Inhibits viral DNA replication by competing with guanosine triphosphate for viral DNA polymerase
- Hydrocortisone: Exerts anti-inflammatory and immunosuppressive effects
Indications
- Treatment of herpes labialis (cold sores)
Common Dosage Forms
- Topical cream
Typical Dosage
- Apply a thin layer to affected area 5 times a day for 5 days
Pediatric Dosage
- Consult healthcare provider for appropriate dosage in children
Geriatric Dosage
- No specific dosage adjustments recommended
Side Effects
- Local skin reactions (e.g., burning, stinging, itching)
- Dry skin
- Peeling
- Rash
Contraindications
- Hypersensitivity to acyclovir, hydrocortisone, or any component of the formulation
Pregnancy Category
- Category B: Generally considered safe for use during pregnancy
Lactation Safety
- Use with caution in breastfeeding mothers
Drug Interactions
- No significant drug interactions reported
Overdose Symptoms
- Unlikely with topical application
Antidote for Overdose
- N/A
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Limited systemic absorption due to topical application
- Distribution: Not well studied
- Metabolism: Acyclovir is metabolized in the liver
- Excretion: Mainly through urine
Precautions
- Avoid contact with eyes and mucous membranes
Warnings
- For external use only. Not for ophthalmic use.