Sodium Fusidate (Topical)

Generic Details

Generic Name

Sodium Fusidate Topical

Other Names

  • Fucidin Cream

Drug Class

  • Antibiotic

Chemical Formula

C31H48O6Na

Molecular Weight

538.71 g/mol

Mechanism of Action

  • Inhibits bacterial protein synthesis by binding to elongation factor G (EF-G) resulting in the inhibition of translocation step of protein synthesis.

Indications

  • Topical treatment of skin infections caused by bacteria, such as impetigo, infected dermatitis, and infected cuts and grazes.

Common Dosage Forms

  • Cream

Typical Dosage

  • Apply a thin layer to the affected area 2-3 times a day.

Pediatric Dosage

  • As per physician's recommendation based on the child's weight and condition.

Geriatric Dosage

  • No specific dosage adjustment needed, but careful monitoring is essential.

Side Effects

  • Local irritation, redness, itching, burning sensation at the site of application.

Contraindications

  • Hypersensitivity to fusidic acid or any component of the product.

Pregnancy Category

  • Safety during pregnancy has not been established. Use only if clearly needed.

Lactation Safety

  • Limited data available. Caution advised; consult healthcare provider.

Drug Interactions

  • No significant drug interactions reported. However, consult healthcare provider for individual cases.

Overdose Symptoms

  • Unlikely with topical use, but may lead to increased side effects if excessive cream is applied.

Antidote for Overdose

  • No specific antidote. Supportive care for symptomatic treatment.

Storage Conditions

  • Store at room temperature away from moisture and heat.

Pharmacokinetics

  • Absorption: Minimal systemic absorption through intact skin.
  • Distribution: Not well characterized.
  • Metabolism: Limited metabolism.
  • Excretion: Primarily excreted unchanged in bile.

Precautions

  • Avoid contact with eyes, mucous membranes, and open wounds.

Warnings

  • For external use only. Not for ophthalmic use.

Others

  • Do not cover the treated area with a dressing or bandage unless instructed by a healthcare provider.