Spiramycin

Generic Name

Spiramycin

Other Names

• Rovamycin

Drug Class

• Macrolide Antibiotic

Chemical Formula

C43H75NO14

Molecular Weight

843.07 g/mol

Mechanism of Action

• Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit

Indications

• Treatment of bacterial infections such as respiratory tract infections, skin and soft tissue infections, and genitourinary tract infections

Common Dosage Forms

• Tablet
• Injection

Typical Dosage

• 500 mg every 6 hours

Pediatric Dosage

• Dosing based on weight and age, consult pediatrician

Geriatric Dosage

• Dosing adjustment may be required, consult healthcare provider

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Allergic reactions like rash or itching

Contraindications

• Hypersensitivity to spiramycin or other macrolide antibiotics

Pregnancy Category

• Category B - No evidence of risk in humans

Lactation Safety

• Consider risk versus benefit during lactation

Drug Interactions

• May interact with anticoagulants, theophylline, and ergot alkaloids

Overdose Symptoms

• Nausea
• Vomiting
• Diarrhea
• Hypersensitivity reactions

Antidote for Overdose

• No specific antidote, symptomatic treatment

Storage Conditions

• Store at room temperature away from moisture and heat

Pharmacokinetics

• Absorption: Well-absorbed orally
• Distribution: Distributed widely in body tissues
• Metabolism: Partially metabolized in the liver
• Excretion: Excreted mainly in the bile

Precautions

• Monitor for signs of allergic reactions during treatment

Warnings

• Avoid use in patients with known hypersensitivity to macrolide antibiotics

Others

• Avoid alcohol during treatment as it may cause disulfiram-like reactions