Streptokinase
Generic Details
Generic Name
Streptokinase
Other Names
- Streptase
- Streptokinase-PAM
Drug Class
- Thrombolytic agent
Chemical Formula
Not applicable (biologic)
Molecular Weight
Approximately 47,000 Daltons
Mechanism of Action
- Converts plasminogen to plasmin, which helps dissolve blood clots
Indications
- Acute myocardial infarction
- Deep vein thrombosis
- Pulmonary embolism
- Arterial thrombosis
Common Dosage Forms
- Lyophilized powder for reconstitution
Typical Dosage
- 1.5 million IU over 60 minutes for myocardial infarction
Pediatric Dosage
- Safety and effectiveness not established in pediatric patients
Geriatric Dosage
- Dosing adjustment may be necessary in elderly patients
Side Effects
- Bleeding
- Hypotension
- Allergic reactions
- Fever
- Nausea
Contraindications
- Active bleeding
- History of stroke
- Severe uncontrolled hypertension
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- No data available, caution advised
Drug Interactions
- Anticoagulants
- Antiplatelet agents
- Thrombolytics
Overdose Symptoms
- Severe bleeding
Antidote for Overdose
- Aminocaproic acid
Storage Conditions
- Store at controlled room temperature (20-25°C)
Pharmacokinetics
- Absorption: Not applicable (administered intravenously)
- Distribution: Rapidly distributed to plasma and extravascular space
- Metabolism: Not extensively metabolized
- Excretion: Mainly eliminated unchanged in the urine
Precautions
- Monitor for signs of bleeding
- Use with caution in patients with recent surgery or trauma
Warnings
- Risk of bleeding
- Thrombolytic therapy carries risk of reperfusion arrhythmias
Others
- Streptokinase is derived from beta-hemolytic streptococci bacteria