Sucralfate
Generic Details
Generic Name
Sucralfate
Other Names
- Carafate
Drug Class
- Antiulcer Agent
Chemical Formula
C12H22O19S
Molecular Weight
854.00 g/mol
Mechanism of Action
- Forms a protective barrier over ulcers and erosions, promoting healing.
Indications
- Peptic ulcers
- Gastroesophageal reflux disease (GERD)
- Stress ulcers
- Prevention of ulcers caused by NSAIDs
Common Dosage Forms
- Tablet
- Suspension
Typical Dosage
- 1 g four times a day on an empty stomach
Pediatric Dosage
- Dosage based on weight and severity of condition. Consult a pediatrician.
Geriatric Dosage
- May require dosage adjustment based on renal function. Consult a healthcare provider.
Side Effects
- Constipation
- Nausea
- Flatulence
- Diarrhea
Contraindications
- Hypersensitivity to sucralfate
Pregnancy Category
- Category B - No proven risk in humans
Lactation Safety
- Considered safe while breastfeeding
Drug Interactions
- May bind to and decrease absorption of other drugs. Administer other medications 2 hours before sucralfate.
Overdose Symptoms
- Unknown
Antidote for Overdose
- No specific antidote. Supportive care may be needed.
Storage Conditions
- Store at room temperature away from moisture and heat.
Pharmacokinetics
- Absorption: Poorly absorbed systemically
- Distribution: Local effect on gastrointestinal mucosa
- Metabolism: Not metabolized
- Excretion: Primarily excreted in the feces
Precautions
- Caution in patients with renal impairment
Warnings
- Administer 2 hours apart from other medications to prevent interactions.