Neomycin Sulfate + Bacitracin Zinc
Generic Details
Generic Name
Neomycin Sulfate Bacitracin Zinc
Other Names
- Neosporin
Drug Class
- Topical Antibiotic Combination
Chemical Formula
C23H48N6O17S
Molecular Weight
712.72 g/mol
Mechanism of Action
- Neomycin and bacitracin inhibit bacterial protein synthesis, while zinc aids in wound healing.
Indications
- Skin infections
- Minor cuts
- Burns
- Scrapes
- Wound healing
Common Dosage Forms
- Topical ointment
- Topical cream
Typical Dosage
- Apply a thin layer on the affected area 1-3 times daily
Pediatric Dosage
- As directed by a healthcare provider
Geriatric Dosage
- May require dose adjustment based on renal function
Side Effects
- Skin irritation
- Allergic reactions
- Burning sensation at the application site
Contraindications
- Hypersensitivity to any component of the formulation
Pregnancy Category
- Category C - Safety not established
Lactation Safety
- Use with caution, may be excreted into breast milk
Drug Interactions
- Limited systemic absorption reduces the risk of significant interactions
Overdose Symptoms
- Unlikely with topical use
Antidote for Overdose
- N/A - Overdose management is supportive and symptomatic
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Limited systemic absorption
- Distribution: Not well characterized
- Metabolism: Not metabolized systemically
- Excretion: Primarily excreted unchanged in urine
Precautions
- Avoid contact with eyes, nose, mouth, and other mucous membranes
Warnings
- Discontinue use if skin irritation occurs
- Not for deep or puncture wounds
Others
- Do not use over large areas of the body or for a prolonged period without medical advice