Tamoxifen Citrate
Generic Details
Generic Name
Tamoxifen Citrate
Other Names
- Nolvadex
Drug Class
- Selective Estrogen Receptor Modulator (SERM)
Chemical Formula
C32H37NO8
Molecular Weight
563.64 g/mol
Mechanism of Action
- Blocks the action of estrogen on breast cells by binding to estrogen receptors
Indications
- Breast cancer treatment
- Breast cancer prevention in high-risk individuals
- Infertility treatment in women with anovulatory disorders
Common Dosage Forms
- Tablet
- Liquid solution
Typical Dosage
- 20 mg daily for breast cancer treatment
Pediatric Dosage
- Not recommended for use in children
Geriatric Dosage
- Dosage adjustments may be required in elderly patients
Side Effects
- Hot flashes
- Vaginal discharge
- Nausea
- Fatigue
- Menstrual changes
Contraindications
- Pregnancy
- History of blood clots
- Severe liver disease
Pregnancy Category
- D
Lactation Safety
- Limited data available, caution advised
Drug Interactions
- Warfarin
- Selective serotonin reuptake inhibitors (SSRIs)
Overdose Symptoms
- Dizziness
- Tremor
- Seizures
Antidote for Overdose
- No specific antidote, management is supportive
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well-absorbed orally
- Distribution: Highly bound to plasma proteins
- Metabolism: Metabolized in the liver
- Excretion: Excreted in feces and urine
Precautions
- Regular monitoring of liver function tests during treatment
- Increased risk of endometrial cancer
Warnings
- Increased risk of thromboembolic events
- Increased risk of cataracts