Telbivudine

Generic Name

Telbivudine

Other Names

• LdT

Drug Class

• Antiviral

Chemical Formula

C10H14N2O5

Molecular Weight

242.23 g/mol

Mechanism of Action

• Inhibits Hepatitis B Virus DNA Polymerase

Indications

• Treatment of chronic hepatitis B

Common Dosage Forms

• Tablet

Typical Dosage

• 600 mg once daily for adults

Pediatric Dosage

• Not established

Geriatric Dosage

• Adjust dosage based on renal function

Side Effects

• Nausea
• Fatigue
• Headache
• Dizziness

Contraindications

• Hypersensitivity to telbivudine

Pregnancy Category

• Category B

Lactation Safety

• Limited data available, caution advised

Drug Interactions

• No clinically significant interactions reported

Overdose Symptoms

• Lactic acidosis
• Exacerbation of adverse reactions

Antidote for Overdose

• Supportive care

Storage Conditions

• Store at room temperature away from light and moisture

Pharmacokinetics

• Absorption: Rapidly absorbed
• Distribution: Distributed widely in body tissues
• Metabolism: Primarily eliminated unchanged in urine
• Excretion: Mainly renally excreted

Precautions

• Monitor for signs of myopathy
• Monitor renal function

Warnings

• May cause severe acute exacerbations of hepatitis B upon discontinuation

Others

• Regular monitoring of liver function tests recommended during treatment