Telmisartan
Generic Details
Generic Name
Telmisartan
Other Names
- Micardis
Drug Class
- Angiotensin II Receptor Blocker
Chemical Formula
C33H30N4O2
Molecular Weight
514.62 g/mol
Mechanism of Action
- Blocks the binding of angiotensin II to angiotensin type 1 receptors, leading to vasodilation and reducing blood pressure
Indications
- Hypertension
- Prevention of cardiovascular events in patients at risk
Common Dosage Forms
- Tablet
Typical Dosage
- 20-80 mg once daily
Pediatric Dosage
- Not recommended for use in children under 18 years
Geriatric Dosage
- Dosage adjustment may be necessary based on renal function
Side Effects
- Hypotension
- Hyperkalemia
- Dizziness
- Headache
- Fatigue
Contraindications
- History of angioedema with previous ACE inhibitor or ARB therapy
- Pregnancy
Pregnancy Category
- D
Lactation Safety
- May pass into breast milk, not recommended during breastfeeding
Drug Interactions
- Potassium-sparing diuretics
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Lithium
Overdose Symptoms
- Hypotension
- Bradycardia
Antidote for Overdose
- Supportive care and monitoring
Storage Conditions
- Store at room temperature (20-25°C)
Pharmacokinetics
- Absorption: Rapid and complete
- Distribution: Extensively protein-bound
- Metabolism: Primarily hepatic via conjugation to inactive metabolites
- Excretion: Urinary and fecal
Precautions
- Renal impairment
- Hepatic impairment
- Dehydration
Warnings
- Avoid in patients with bilateral renal artery stenosis
Others
- Regular monitoring of blood pressure and renal function is recommended during therapy