Bacitracin Zinc + Polymyxin B Sulfate
Generic Details
Generic Name
Bacitracin-Zinc-Polymyxin B Sulfate
Other Names
- Bacitracin Zinc Polymyxin B Sulfate Ointment
Drug Class
- Topical Antibiotic
Chemical Formula
Not Available
Molecular Weight
Not Available
Mechanism of Action
- Bacitracin inhibits bacterial cell wall synthesis by interfering with dephosphorylation of the lipid carrier undecaprenyl phosphate.
- Polymyxin B disrupts the bacterial cell membrane by binding to phospholipids.
Indications
- Topical treatment of superficial skin infections caused by susceptible bacteria.
Common Dosage Forms
- Ointment
Typical Dosage
- Apply a thin layer to affected area 1 to 3 times daily.
Pediatric Dosage
- Use under the guidance of a healthcare provider.
Geriatric Dosage
- Use under the guidance of a healthcare provider.
Side Effects
- Local irritation
- Allergic contact dermatitis
Contraindications
- Hypersensitivity to bacitracin, polymyxin B, or any component of the formulation.
Pregnancy Category
- Safety not established, consult healthcare provider.
Lactation Safety
- Safety not established, consult healthcare provider.
Drug Interactions
- No significant drug interactions reported.
Overdose Symptoms
- Unlikely with topical use.
Antidote for Overdose
- Not applicable for topical use.
Storage Conditions
- Store at room temperature, away from moisture and heat.
Pharmacokinetics
- Absorption: Limited systemic absorption after topical application.
- Distribution: Not well described for topical use.
- Metabolism: Not well described for topical use.
- Excretion: Not well described for topical use.
Precautions
- Avoid contact with eyes or mucous membranes.
Warnings
- For external use only.