Tenofovir Disoproxil
Generic Details
Generic Name
Tenofovir Disoproxil
Other Names
- TDF
Drug Class
- Antiretroviral Agent
- Nucleotide Reverse Transcriptase Inhibitor
Chemical Formula
C19H30N5O10P
Molecular Weight
635.44 g/mol
Mechanism of Action
- Inhibits the activity of the enzyme reverse transcriptase, thereby interfering with viral replication
Indications
- HIV-1 infection
- Chronic Hepatitis B
Common Dosage Forms
- Tablet
Typical Dosage
- 300 mg once daily for HIV-1 infection
- 300 mg once daily for Chronic Hepatitis B
Pediatric Dosage
- Dosage varies based on body weight and age
Geriatric Dosage
- Dosage adjustment may be needed based on renal function
Side Effects
- Nausea
- Diarrhea
- Fatigue
- Headache
- Renal toxicity
- Bone density loss
Contraindications
- Hypersensitivity to tenofovir or any components of the formulation
Pregnancy Category
- Category B
Lactation Safety
- Limited data available; caution advised
Drug Interactions
- Didanosine
- Adefovir
- Nucleoside analogues
Overdose Symptoms
- Acute renal failure
- Lactic acidosis
Antidote for Overdose
- Supportive care and monitoring of renal function
Storage Conditions
- Store at room temperature (20-25°C)
Pharmacokinetics
- Absorption: Rapidly converted into tenofovir in the body
- Distribution: Distributed to tissues including the kidneys
- Metabolism: Hepatic
- Excretion: Mainly through urine
Precautions
- Renal impairment
- Bone health monitoring
- HIV resistance testing
Warnings
- Risk of lactic acidosis
- Risk of renal toxicity
Others
- Regular monitoring of renal function is recommended during treatment