Tenoxicam
Generic Details
Generic Name
Tenoxicam
Other Names
- Tilcotil
Drug Class
- Nonsteroidal Anti-Inflammatory Drug (NSAID)
Chemical Formula
C13H11N3O4S2
Molecular Weight
337.37 g/mol
Mechanism of Action
- Inhibits cyclooxygenase enzymes leading to decreased prostaglandin synthesis
Indications
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Painful menstruation
Common Dosage Forms
- Tablet
- Injection
Typical Dosage
- 20 mg once daily
Pediatric Dosage
- Safety and efficacy not established in children
Geriatric Dosage
- Consider lower starting dose due to increased risk of adverse effects
Side Effects
- Gastrointestinal upset
- Ulcers
- Bleeding
- Kidney toxicity
- Skin reactions
Contraindications
- History of gastrointestinal bleeding or perforation
- Severe heart failure
- Hypersensitivity to tenoxicam or other NSAIDs
Pregnancy Category
- Category C - Avoid in the third trimester
Lactation Safety
- Limited data available, use caution
Drug Interactions
- Increased risk of bleeding with anticoagulants
- Reduced effectiveness of diuretics
- Potential interaction with lithium leading to toxicity
Overdose Symptoms
- Nausea
- Vomiting
- Abdominal pain
- Drowsiness
- Seizures
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed after oral administration
- Distribution: Widely distributed in the body, including synovial fluid
- Metabolism: Metabolized in the liver via conjugation
- Excretion: Primarily excreted in urine
Precautions
- Monitor for signs of gastrointestinal bleeding
- Avoid concurrent use of other NSAIDs
- Monitor renal function
Warnings
- Increased risk of cardiovascular events and gastrointestinal bleeding
Others
- Tenoxicam should be used at the lowest effective dose for the shortest duration possible to minimize the risk of side effects.