Rhubarb Extract + Salicylic Acid

Generic Details

Generic Name

Rhubarb Extract Salicylic Acid

Other Names

  • Rhubarb Salicylate

Drug Class

  • Salicylates

Chemical Formula

C20H22O6

Molecular Weight

358.387 g/mol

Mechanism of Action

  • The salicylic acid component inhibits prostaglandin synthesis by blocking the enzyme cyclooxygenase, thereby exerting anti-inflammatory, analgesic, and antipyretic effects.

Indications

  • Rheumatic disorders
  • Acute musculoskeletal conditions
  • Pain relief
  • Fever reduction

Common Dosage Forms

  • Tablet
  • Capsule
  • Topical cream

Typical Dosage

  • Oral: 325-650 mg every 4-6 hours as needed
  • Topical: Apply a thin layer to affected area 2-3 times daily

Pediatric Dosage

  • Consult healthcare provider for appropriate dosage based on weight and condition

Geriatric Dosage

  • Lower starting dose may be recommended due to increased risk of side effects

Side Effects

  • Gastric irritation
  • Ulceration
  • Bleeding
  • Renal impairment
  • Hypersensitivity reactions

Contraindications

  • Hypersensitivity to salicylates
  • Peptic ulcer disease
  • Hemophilia
  • Severe renal or hepatic impairment

Pregnancy Category

  • Category C - Safety in pregnancy not established, use with caution

Lactation Safety

  • Limited data available, exercise caution

Drug Interactions

  • Anticoagulants
  • Oral corticosteroids
  • Methotrexate
  • NSAIDs

Overdose Symptoms

  • Tinnitus
  • Hyperventilation
  • Hyperthermia
  • Metabolic acidosis

Antidote for Overdose

  • Activated charcoal
  • Alkalinization of urine

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Well-absorbed from the gastrointestinal tract
  • Distribution: Widely distributed throughout the body
  • Metabolism: Primarily metabolized in the liver via glucuronidation and oxidation
  • Excretion: Mainly excreted in the urine as metabolites

Precautions

  • Monitor renal function
  • Avoid concurrent use of other NSAIDs

Warnings

  • May increase the risk of gastrointestinal bleeding
  • Avoid in patients with aspirin allergy

Others

  • Avoid prolonged use without medical supervision due to the risk of salicylate toxicity