Salmeterol + Fluticasone Propionate
Generic Details
Generic Name
Salmeterol-Fluticasone-Propionate
Other Names
- Seretide
- Advair
Drug Class
- Long-acting beta-agonist (LABA)
- Inhaled corticosteroid (ICS)
Chemical Formula
C25H31F3O5S
Molecular Weight
500.57 g/mol
Mechanism of Action
- Salmeterol: Selective beta2-adrenergic agonist
- Fluticasone: Corticosteroid that inhibits inflammation
Indications
- Asthma
- Chronic obstructive pulmonary disease (COPD)
Common Dosage Forms
- Inhalation powder
- Inhalation aerosol
Typical Dosage
- Salmeterol 50 mcg/Fluticasone 100 mcg, twice daily
Pediatric Dosage
- Dosage should be individualized based on weight and age
Geriatric Dosage
- Dose adjustment may be required based on renal and hepatic function
Side Effects
- Throat irritation
- Hoarseness
- Cough
- Headache
- Nausea
Contraindications
- Hypersensitivity to salmeterol or fluticasone
- Status asthmaticus
Pregnancy Category
- C (Salmeterol)
- C (Fluticasone)
Lactation Safety
- L3 (Salmeterol)
- L2 (Fluticasone)
Drug Interactions
- Beta-blockers
- Ketoconazole
- Ritonavir
Overdose Symptoms
- Tremor
- Headache
- Palpitations
Antidote for Overdose
Not applicable
Storage Conditions
- Store at room temperature between 68-77°F (20-25°C)
- Protect from moisture and light
Pharmacokinetics
- Absorption: Well absorbed from the lungs
- Distribution: Protein binding: Fluticasone 91%, Salmeterol 96%
- Metabolism: Hepatic
- Excretion: Mainly in feces
Precautions
- Monitor for signs of systemic corticosteroid effects
- Do not use for acute asthma attacks
Warnings
- Increased risk of asthma-related deaths
- Not a rescue inhaler