Terazosin Hydrochloride
Generic Details
Generic Name
Terazosin Hydrochloride
Other Names
- Terazosin HCl
Drug Class
- Alpha-1 blocker
Chemical Formula
C19H25ClN6O4S
Molecular Weight
459.959 g/mol
Mechanism of Action
- Blocks alpha-1 adrenergic receptors leading to vasodilation
Indications
- Hypertension
- Benign prostatic hyperplasia (BPH)
Common Dosage Forms
- Tablet
Typical Dosage
- 1-5 mg once daily for hypertension
- 1-10 mg once daily for BPH
Pediatric Dosage
- Not established
Geriatric Dosage
- Dosage adjustment may be necessary in the elderly
Side Effects
- Dizziness
- Headache
- Fatigue
- Orthostatic hypotension
- Retrograde ejaculation
Contraindications
- Hypotension
- Severe liver impairment
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Caution advised
Drug Interactions
- Antihypertensives
- PDE-5 inhibitors
- Alpha-blockers
Overdose Symptoms
- Hypotension
- Tachycardia
- Drowsiness
Antidote for Overdose
- Supportive measures
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed
- Distribution: Distribution volume: 5–6 L/kg
- Metabolism: Extensively metabolized in the liver
- Excretion: Excreted mainly via feces and urine
Precautions
- Caution in patients with hepatic impairment
- Monitor blood pressure regularly
Warnings
- Do not abruptly discontinue therapy
Others
- May cause first-dose orthostatic hypotension