Terbinafine Hydrochloride
Generic Details
Generic Name
Terbinafine Hydrochloride
Other Names
- Lamisil
- Tineafine
- Terbifin
Drug Class
- Antifungal
Chemical Formula
C21H26ClN
Molecular Weight
327.89 g/mol
Mechanism of Action
- Inhibits squalene epoxidase enzyme, leading to ergosterol deficiency in fungal cell membranes
Indications
- Treatment of fungal infections such as athlete's foot, ringworm, and jock itch
Common Dosage Forms
- Tablet
- Cream
- Gel
Typical Dosage
- 250 mg once daily for oral tablets
Pediatric Dosage
- Dosage may vary based on weight and age, consult a healthcare provider
Geriatric Dosage
- Dosage adjustment may be needed based on renal function
Side Effects
- Nausea
- Diarrhea
- Headache
- Liver function test abnormalities
- Skin rash
Contraindications
- Hypersensitivity to terbinafine
- Severe hepatic impairment
Pregnancy Category
- B - Animal reproduction studies have failed to demonstrate a risk to the fetus
Lactation Safety
- Possibly safe, but consult healthcare provider before use
Drug Interactions
- Cimetidine
- Fluconazole
- Rifampin
Overdose Symptoms
- Nausea
- Vomiting
- Abdominal pain
Antidote for Overdose
- No specific antidote, symptomatic and supportive treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: High oral bioavailability
- Distribution: Well-distributed in tissues
- Metabolism: Hepatic metabolism
- Excretion: Urine (70%) and feces (14%)
Precautions
- Monitor liver function tests during treatment
- Avoid alcohol consumption during therapy
Warnings
- May cause liver failure in rare cases
- Discontinue if signs of liver injury develop
Others
- Avoid sunlight exposure during treatment as photosensitivity may occur