Terbutaline Sulfate
Generic Details
Generic Name
Terbutaline Sulfate
Other Names
- Brethine
- Bricanyl
Drug Class
- Beta-2 Adrenergic Agonist
Chemical Formula
C12H19NO3S
Molecular Weight
275.35 g/mol
Mechanism of Action
- Selective beta-2 adrenergic agonist leading to bronchodilation
Indications
- Asthma
- Chronic obstructive pulmonary disease (COPD)
- Bronchospasm
Common Dosage Forms
- Tablet
- Syrup
- Inhaler
Typical Dosage
- 2.5-5 mg orally every 4-6 hours as needed for bronchospasm
Pediatric Dosage
- Dosage needs to be adjusted based on weight and severity of condition
Geriatric Dosage
- Lower initial doses may be required due to decreased clearance
Side Effects
- Tachycardia
- Tremors
- Nervousness
- Headache
- Hypokalemia
Contraindications
- Hypersensitivity to terbutaline sulfate
- Uncontrolled hypertension
- Cardiac arrhythmias
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- Compatible with breastfeeding
Drug Interactions
- Beta-blockers may antagonize the effects of terbutaline sulfate
Overdose Symptoms
- Severe tremors
- Seizures
- Hypokalemia
- Cardiac arrhythmias
Antidote for Overdose
- Supportive care and beta-blockers if necessary
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed after oral administration
- Distribution: Crosses the placenta, excreted in breast milk
- Metabolism: Mainly hepatic
- Excretion: Primarily renal
Precautions
- Caution in patients with cardiovascular disorders
- Monitor blood pressure and heart rate
Warnings
- Do not exceed recommended dose
- Discontinue use if paradoxical bronchospasm occurs