Testosterone Undecanoate
Generic Details
Generic Name
Testosterone Undecanoate
Other Names
- Andriol
- Nebido
- Aveed
Drug Class
- Anabolic steroid
- Androgen
Chemical Formula
C30H48O3
Molecular Weight
456.71 g/mol
Mechanism of Action
- Binds to androgen receptors to promote the normal growth and development of male sex organs and secondary sexual characteristics
Indications
- Testosterone replacement therapy in males with hypogonadism
- Delayed puberty in males
Common Dosage Forms
- Oral capsules
- Injectable solution
Typical Dosage
- Oral: 40-120 mg daily
- Injectable: 750 mg every 10-14 weeks
Pediatric Dosage
- Not established
Geriatric Dosage
- Dosage adjustment may be necessary based on age and clinical response
Side Effects
- Acne
- Fluid retention
- Increased blood pressure
- Changes in libido
- Gynecomastia
- Liver toxicity
Contraindications
- Prostate or breast cancer
- Pregnancy
- Hypersensitivity to the drug
Pregnancy Category
- X - Contraindicated in pregnancy
Lactation Safety
- Not recommended during breastfeeding due to potential masculinization of the female fetus
Drug Interactions
- Warfarin
- Insulin
- Cyclosporine
Overdose Symptoms
- Acne
- Aggressiveness
- Hair loss
- Liver damage
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at controlled room temperature (20-25°C)
Pharmacokinetics
- Absorption: Slow and variable absorption from the gastrointestinal tract
- Distribution: Widely distributed, mainly bound to sex hormone-binding globulin and albumin
- Metabolism: Metabolized in the liver
- Excretion: Primarily excreted in the urine as metabolites
Precautions
- Monitor liver function tests regularly
- Monitor for signs of virilization in females
- Monitor prostate-specific antigen (PSA) levels in males
Warnings
- May increase the risk of prostate hypertrophy or carcinoma
- May worsen sleep apnea
- May cause polycythemia
Others
- Requires monitoring of hormone levels during therapy for optimization