Tiemonium Methylsulphate
Generic Details
Generic Name
Tiemonium-Methylsulphate
Other Names
- Tiemonium Methylsulfate
Drug Class
- Antimuscarinic
- Antispasmodic
Chemical Formula
CᴋH₁₈N₂O₄S
Molecular Weight
334.42 g/mol
Mechanism of Action
- Inhibits muscarinic acetylcholine receptors in the smooth muscle of the gastrointestinal tract.
Indications
- Irritable bowel syndrome
- Spasmodic dysmenorrhea
- Functional gastrointestinal disorders
Common Dosage Forms
- Tablet
- Injection
Typical Dosage
- 50-100 mg thrice daily
Pediatric Dosage
- Dosage based on weight and usually lower than adult dosage
Geriatric Dosage
- May require lower initial dosage due to decreased renal function
Side Effects
- Dry mouth
- Blurred vision
- Constipation
- Urinary retention
Contraindications
- Hypersensitivity to tiemonium-methylsulphate
- Narrow-angle glaucoma
Pregnancy Category
- Not recommended during pregnancy
Lactation Safety
- Limited data available, consult healthcare provider
Drug Interactions
- Potential interactions with other anticholinergic drugs
Overdose Symptoms
- Severe dry mouth
- Flushing
- Tachycardia
Antidote for Overdose
- No specific antidote, treatment is supportive
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Wide distribution in the body
- Metabolism: Partially metabolized in the liver
- Excretion: Excreted primarily in the urine
Precautions
- Use with caution in patients with prostatic hypertrophy
- Monitor for signs of anticholinergic toxicity
Warnings
- Avoid abrupt withdrawal in patients on long-term therapy
- May cause drowsiness or blurred vision