Tinidazole

Generic Details

Generic Name

Tinidazole

Other Names

  • Fasigyn
  • Tindamax

Drug Class

  • Antibacterial
  • Antiprotozoal

Chemical Formula

C8H13N3O4S

Molecular Weight

247.27 g/mol

Mechanism of Action

  • Inhibits DNA synthesis and disrupts the DNA helical structure of microbial pathogens

Indications

  • Treatment of bacterial infections
  • Treatment of parasitic infections such as giardiasis and amebiasis

Common Dosage Forms

  • Tablet
  • Suspension

Typical Dosage

  • 500 mg once daily for 3 to 5 days
  • 2 g single dose for trichomoniasis

Pediatric Dosage

  • Dosage should be determined by a healthcare provider based on the child’s weight and condition

Geriatric Dosage

  • Dosage adjustment may be needed based on renal function

Side Effects

  • Nausea
  • Metallic taste
  • Headache
  • Dizziness
  • Vomiting
  • Diarrhea

Contraindications

  • Hypersensitivity to tinidazole or other nitroimidazole derivatives

Pregnancy Category

  • C - Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Lactation Safety

  • Limited data available; caution advised. Consider the benefits of breastfeeding along with the mother's clinical need for the medication.

Drug Interactions

  • Alcohol (disulfiram-like reaction)
  • Warfarin (increased risk of bleeding)

Overdose Symptoms

  • Nausea
  • Vomiting
  • Metallic taste in mouth

Antidote for Overdose

  • No specific antidote, treatment is supportive

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Well absorbed orally
  • Distribution: Widely distributed in tissues and body fluids
  • Metabolism: Metabolized in the liver
  • Excretion: Mainly excreted in the urine

Precautions

  • Caution in patients with a history of blood disorders
  • May cause dizziness or drowsiness, caution when driving or operating machinery

Warnings

  • Avoid alcohol consumption during and for at least 3 days after completion of tinidazole therapy

Others

  • Avoid using while breastfeeding unless the benefits outweigh the risks