Teicoplanin

Generic Details

Generic Name

Teicoplanin

Other Names

  • Teicoplanin Hydrochloride

Drug Class

  • Glycopeptide Antibiotic

Chemical Formula

C88H94Cl2N8O34S2

Molecular Weight

1940.76 g/mol

Mechanism of Action

  • Inhibits bacterial cell wall synthesis by binding to peptidoglycan precursors

Indications

  • Treatment of severe gram-positive bacterial infections, such as MRSA (Methicillin-Resistant Staphylococcus Aureus), endocarditis, and skin infections

Common Dosage Forms

  • Intravenous powder for solution

Typical Dosage

  • 400 mg loading dose, followed by 200 mg every 24 hours

Pediatric Dosage

  • Dosing based on weight and age, to be determined by a pediatrician

Geriatric Dosage

  • Dosing adjustment may be required based on renal function

Side Effects

  • Nausea, vomiting, diarrhea, rash, nephrotoxicity, hepatotoxicity, thrombocytopenia

Contraindications

  • Hypersensitivity to teicoplanin or other glycopeptide antibiotics

Pregnancy Category

  • Category C - Risk cannot be ruled out

Lactation Safety

  • Limited data available, use caution or consider alternative

Drug Interactions

  • May enhance the effects of other nephrotoxic or ototoxic drugs

Overdose Symptoms

  • Renal failure, hearing loss, liver damage

Antidote for Overdose

  • No specific antidote, manage symptoms and provide supportive care

Storage Conditions

  • Store powder for solution at controlled room temperature (25°C)

Pharmacokinetics

  • Absorption: Not absorbed orally, administered parenterally
  • Distribution: Widely distributed in tissues
  • Metabolism: Metabolized in the liver
  • Excretion: Primarily excreted in the urine

Precautions

  • Monitor renal and liver function during therapy

Warnings

  • Prolonged use may result in superinfection with nonsusceptible organisms

Others

  • Teicoplanin monitoring in blood levels may be necessary to ensure therapeutic efficacy