Basiliximab

Generic Details

Generic Name

Basiliximab

Other Names

  • Simulect

Drug Class

  • Immunosuppressant

Chemical Formula

C6642H10108N1718O2024S44

Molecular Weight

144554.0 g/mol

Mechanism of Action

  • Interleukin-2 receptor antagonist

Indications

  • Prophylaxis of rejection in renal transplantation

Common Dosage Forms

  • Solution for intravenous infusion

Typical Dosage

  • 20 mg administered as two 10 mg IV doses

Pediatric Dosage

  • Safety and effectiveness not established in pediatric patients

Geriatric Dosage

  • Adjust dosage based on renal function

Side Effects

  • Hypersensitivity reactions, infections, gastrointestinal disturbances, leukopenia

Contraindications

  • Hypersensitivity to basiliximab or any component of the formulation

Pregnancy Category

  • Category C - may be used if benefits outweigh risks

Lactation Safety

  • Safety not established; caution advised

Drug Interactions

  • Avoid concomitant use with other immunosuppressants

Overdose Symptoms

  • Limited experience with overdose

Antidote for Overdose

  • No specific antidote; manage symptoms and provide supportive care

Storage Conditions

  • Store in the refrigerator at 2°C to 8°C (36°F to 46°F); do not freeze

Pharmacokinetics

  • Absorption: Not applicable (IV administration)
  • Distribution: Concentrates in lymphoid tissues
  • Metabolism: Not extensively metabolized
  • Excretion: Primarily excreted unchanged in urine

Precautions

  • Monitor for signs of hypersensitivity reactions during administration

Warnings

  • Increased risk of infections and malignancies

Others

  • Administer under the supervision of healthcare professionals experienced in immunosuppressive therapy