Tolfenamic acid
Generic Details
Generic Name
Tolfenamic Acid
Other Names
- Tolfenamate
Drug Class
- Nonsteroidal Anti-inflammatory Drug (NSAID)
Chemical Formula
C14H12ClNO2
Molecular Weight
261.70 g/mol
Mechanism of Action
- Inhibition of prostaglandin synthesis through COX inhibition
Indications
- Pain relief
- Inflammation
- Dysmenorrhea
- Fever
Common Dosage Forms
- Tablet
- Capsule
Typical Dosage
- 200-400 mg twice daily
Pediatric Dosage
- Not established
Geriatric Dosage
- Lower doses may be considered due to potential increased risk of adverse effects
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Headache
- Dizziness
- Rash
Contraindications
- History of hypersensitivity to tolfenamic acid or other NSAIDs
- Active peptic ulcer disease
- Severe renal impairment
Pregnancy Category
- Not recommended in the third trimester
Lactation Safety
- Probably compatible with breastfeeding, but caution advised
Drug Interactions
- Warfarin
- Lithium
- ACE inhibitors
Overdose Symptoms
- Severe stomach pain
- Nausea
- Vomiting
- Drowsiness
Antidote for Overdose
- Activated charcoal, supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well-absorbed orally
- Distribution: Highly bound to plasma proteins
- Metabolism: Hepatic metabolism via conjugation and oxidation
- Excretion: Mainly through urine
Precautions
- Monitor for signs of gastrointestinal bleeding
- Avoid in patients with a history of asthma
Warnings
- May increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke
Others
- Tolfenamic acid is not commonly used in many countries; always consult a healthcare professional for personalized advice.