Tolperisone Hydrochloride
Generic Details
Generic Name
Tolperisone Hydrochloride
Other Names
- Tolperisone HCl
Drug Class
- Muscle Relaxant
Chemical Formula
C16H24ClNO
Molecular Weight
291.82 g/mol
Mechanism of Action
- Acts centrally as a selective blocker of voltage-dependent sodium channels
Indications
- Muscle spasms
- Musculoskeletal pain
Common Dosage Forms
- Tablet
- Capsule
Typical Dosage
- 50-150 mg three times a day
Pediatric Dosage
- Not established
Geriatric Dosage
- Lower initial doses due to age-related decrease in metabolism
Side Effects
- Drowsiness
- Dizziness
- Headache
- Nausea
- Dry mouth
Contraindications
- Hypersensitivity to tolperisone
- Severe kidney or liver impairment
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Use with caution, limited data available
Drug Interactions
- Central nervous system depressants
- Alcohol
- CYP2D6 inhibitors
Overdose Symptoms
- Excessive sedation
- Respiratory depression
- Coma
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly and well absorbed after oral administration
- Distribution: Extensively distributed in the body
- Metabolism: Mainly hepatic via CYP2D6 enzyme
- Excretion: Primarily renal elimination
Precautions
- Use with caution in the elderly due to increased sensitivity
- Avoid driving or operating machinery
Warnings
- May cause drowsiness, avoid alcohol consumption
Others
- Tolperisone is not available in all countries, check local availability and regulations