Torasemide
Generic Details
Generic Name
Torasemide
Other Names
- Demadex
Drug Class
- Loop diuretic
Chemical Formula
C16H20N4O3S
Molecular Weight
348.42 g/mol
Mechanism of Action
- Inhibits the Na-K-2Cl transporter in the ascending loop of Henle, leading to diuresis
Indications
- Hypertension
- Edema due to heart failure or renal dysfunction
Common Dosage Forms
- Tablet
- Injection
Typical Dosage
- 10-20 mg once daily in the morning
Pediatric Dosage
- Safety and efficacy not established in children
Geriatric Dosage
- Reduce initial dose due to decreased renal function
Side Effects
- Hypokalemia
- Dehydration
- Hypotension
- Dizziness
Contraindications
- Anuria
- Hypersensitivity to sulfonamides
Pregnancy Category
- C - Use with caution
Lactation Safety
- Compatible with breastfeeding
Drug Interactions
- NSAIDs may reduce diuretic efficacy
- Digoxin levels may increase
Overdose Symptoms
- Severe electrolyte disturbances
- Hypovolemia
Antidote for Overdose
- Symptomatic and supportive treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Protein-bound, mainly to albumin
- Metabolism: Hepatic metabolism to inactive metabolites
- Excretion: Mainly renal excretion
Precautions
- Monitor electrolytes and renal function regularly
Warnings
- Risk of hypokalemia and volume depletion
Others
- Torasemide is often used as an alternative to furosemide in patients with sulfa allergies.