Adapalene + Benzoyl peroxide

Generic Details

Generic Name

Adapalene-Benzoyl Peroxide

Other Names

  • Epiduo
  • TactuPump

Drug Class

  • Topical acne agents

Chemical Formula

C28H28O5.C14H10O4

Molecular Weight

412.52 g/mol (adapalene) + 242.23 g/mol (benzoyl peroxide)

Mechanism of Action

  • Adapalene: Decreases acne formation by normalizing skin cell turnover
  • Benzoyl Peroxide: Works as a keratolytic, bactericidal and anti-inflammatory agent

Indications

  • Acne vulgaris

Common Dosage Forms

  • Gel

Typical Dosage

  • Apply a thin layer to affected areas once daily, in the evening

Pediatric Dosage

  • Safety and efficacy not established in children under 12 years

Geriatric Dosage

  • Use with caution in the elderly

Side Effects

  • Dryness
  • Irritation
  • Erythema
  • Peeling

Contraindications

  • Hypersensitivity to any component of the product

Pregnancy Category

  • Category C - Safety not established; benefit should outweigh risk

Lactation Safety

  • Use with caution in nursing mothers

Drug Interactions

  • Avoid concomitant use with other potentially irritating topical products

Overdose Symptoms

  • Not reported

Antidote for Overdose

  • N/A

Storage Conditions

  • Store at 20°C to 25°C (68°F to 77°F)

Pharmacokinetics

  • Absorption: Minimal systemic absorption
  • Distribution: Not well characterized
  • Metabolism: Adapalene metabolized by CYP2C9, CYP3A4, benzoyl peroxide is metabolized to benzoic acid in the skin
  • Excretion: Primarily through the skin

Precautions

  • Avoid contact with eyes, lips, mouth, and mucous membranes

Warnings

  • May cause photosensitivity; use sunscreen and protective clothing during treatment

Others

  • Always perform a patch test before full application.