Trimetazidine Dihydrochloride
Generic Details
Generic Name
Trimetazidine Dihydrochloride
Other Names
- Vastarel
- TMZ
Drug Class
- Anti-ischemic
- Metabolic Agent
Chemical Formula
C14H22ClN1O2
Molecular Weight
299.78 g/mol
Mechanism of Action
- Selective inhibition of fatty acid oxidation and glucose oxidation
Indications
- Angina pectoris
- Chronic stable angina
- Vertigo and tinnitus of vascular origin
Common Dosage Forms
- Tablet
- Extended-release tablet
Typical Dosage
- 20 mg to 35 mg twice daily
Pediatric Dosage
- Safety and efficacy not established in children
Geriatric Dosage
- Dosage adjustment may be needed based on renal function
Side Effects
- Headache
- Gastrointestinal disturbances
- Dizziness
- Rash
Contraindications
- Hypersensitivity to trimetazidine
- Pregnancy (unless clearly necessary)
Pregnancy Category
- Not classified; use only if clearly needed and under medical supervision
Lactation Safety
- Limited data; consider alternatives or monitor for potential effects
Drug Interactions
- Cimetidine
- Propranolol
- Diltiazem
Overdose Symptoms
- Hypotension
- Bradycardia
- Tachycardia
- Confusion
Antidote for Overdose
- Supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed from the gastrointestinal tract
- Distribution: Protein binding is minimal
- Metabolism: Metabolized in the liver
- Excretion: Primarily excreted unchanged in urine
Precautions
- Renal impairment
- Hepatic impairment
- Patients with parkinsonism
Warnings
- May cause dizziness; caution when driving or operating machinery
Others
- Should not be used for acute angina attacks