Urea (10%)
Generic Details
Generic Name
Urea-10
Other Names
Drug Class
- Topical emollient
Chemical Formula
CH4N2O
Molecular Weight
60.06 g/mol
Mechanism of Action
- Urea is a humectant that works by drawing water into the skin, thereby increasing skin moisture and softening dry, scaly skin.
Indications
- Moisturizing and softening dry, rough, and scaly skin conditions such as eczema, psoriasis, corns, and calluses.
Common Dosage Forms
- Cream
- Lotion
Typical Dosage
- Apply a thin layer of cream or lotion to the affected area 1-2 times daily.
Pediatric Dosage
- Consult a healthcare provider for appropriate pediatric dosage.
Geriatric Dosage
- Consider lower concentrations for elderly patients or consult a healthcare provider.
Side Effects
- Mild stinging or burning may occur upon application.
Contraindications
- Hypersensitivity to urea or any components of the formulation.
Pregnancy Category
- Consult a healthcare provider before use during pregnancy.
Lactation Safety
- Safe for use while breastfeeding; minimal systemic absorption.
Drug Interactions
- No significant drug interactions reported.
Overdose Symptoms
- Unlikely with topical use, but excessive application may cause skin irritation.
Antidote for Overdose
- Symptomatic treatment; wash off excess product and seek medical attention if necessary.
Storage Conditions
- Store at room temperature away from moisture and heat.
Pharmacokinetics
- Absorption: Limited systemic absorption through intact skin.
- Distribution: Not well-documented due to minimal systemic effects.
- Metabolism: Not metabolized.
- Excretion: Primarily excreted unchanged through the urine.
Precautions
- Avoid contact with eyes, mouth, or mucous membranes.
Warnings
- For external use only. Discontinue use if skin irritation develops.