Ursodeoxycholic Acid
Generic Details
Generic Name
Ursodeoxycholic Acid
Other Names
- UDCA
- Urso
- Actigall
Drug Class
- Bile Acid
Chemical Formula
C24H40O4
Molecular Weight
392.57 g/mol
Mechanism of Action
- Dissolution of cholesterol-rich gallstones
- Protective effect on the liver
Indications
- Gallstone dissolution
- Primary biliary cholangitis (PBC)
- Cholestatic liver diseases
Common Dosage Forms
- Capsules
- Tablets
Typical Dosage
- 250-500mg 2-4 times daily
Pediatric Dosage
- Dosage based on weight and medical condition
Geriatric Dosage
- Lower starting doses may be considered
Side Effects
- Diarrhea
- Abdominal pain
- Nausea
- Vomiting
Contraindications
- Hypersensitivity to bile acids
- Acute cholecystitis
- Obstructed biliary channels
Pregnancy Category
- B
Lactation Safety
- Limited data available, use with caution
Drug Interactions
- Cyclosporine
- Cholestyramine
- Oral contraceptives
Overdose Symptoms
- Diarrhea
- Abdominal pain
- Constipation
Antidote for Overdose
- No specific antidote, symptomatic treatment
Storage Conditions
- Store at room temperature
Pharmacokinetics
- Absorption: Incomplete absorption from the gut
- Distribution: Mainly in the liver
- Metabolism: Undergoes hepatic metabolism
- Excretion: Primarily excreted in feces
Precautions
- Monitor liver function tests regularly
- Caution in patients with biliary obstruction
Warnings
- May exacerbate gallbladder symptoms in some patients
Others
- May be used off-label for certain liver conditions