Valsartan
Generic Details
Generic Name
Valsartan
Other Names
- Diovan
Drug Class
- Angiotensin II Receptor Blocker
Chemical Formula
C24H29N5O3
Molecular Weight
435.52 g/mol
Mechanism of Action
- Blocks the binding of angiotensin II to the AT1 receptor in tissues, causing vasodilation and reducing the release of aldosterone
Indications
- Hypertension
- Heart Failure
- Post-Myocardial Infarction
- Diabetic Nephropathy
Common Dosage Forms
- Tablet
Typical Dosage
- 80 mg to 160 mg once daily for hypertension
Pediatric Dosage
- Not established
Geriatric Dosage
- Adjust dosage based on renal function
Side Effects
- Dizziness
- Hyperkalemia
- Hypotension
- Fatigue
- Headache
Contraindications
- History of angioedema
- Pregnancy
- Severe hepatic impairment
Pregnancy Category
- D
Lactation Safety
- L5 - Limited data - Probably compatible
Drug Interactions
- Lithium
- NSAIDs
- Potassium-sparing diuretics
Overdose Symptoms
- Hypotension
- Bradycardia
Antidote for Overdose
- Activated charcoal
- Supportive measures
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well-absorbed
- Distribution: Extensively distributed in tissues
- Metabolism: Primarily hepatic via CYP2C9
- Excretion: Mainly via feces and urine
Precautions
- Renal impairment
- Hyperkalemia
- Dehydration
Warnings
- Risk of angioedema
- Fetal toxicity
Others
- May be taken with or without food